Abstract
Purpose :
The caract surgery effects on the central Endothelial Mosaic (EM) are known, but they are not at the most proximal and distal areas of the incision, especially many years after. To evaluate corneal EM after phacoemulsification (Phaco) + Intraocular Lens (IOL) with CCI many years after the surgery.
Methods :
Cross sectional study of the EM in a sample of 27 eyes after PHACO + IOL - SN60WF AcrySof® IQ Monofocal IOL (Alcon, Texas) with temporal CCI. The post surgical time of the EM examination: From 2.1 to 14.1 years and average 6.2±3.6 years. Inclusion criteria: The sampling process in each included EM examination by Specular Microscopy (SM) with reliability degree of 95% and relative error (sample error) < 0.05 (5%) according the Cells Analyzer USA Patent software (Technicall, Brazil). Each patient was submited to Specular Microscopy (SM) at CCI, central, and nasal peripheral áreas, by the same expert examiner with BioOptics LSM 2500 Contact SM (Figure 1A). Endothelial Cell Density (ECD), Cell Area (CA), polymegethism by Coefficient of Variation (CV), and pleomorphism by Percentage of Hexagonal Cells (HEX) were calculated by Bambi Plus 2500 software. Non-parametric Wilcoxon test, p< 0.05 was used to compare the variables described by mean and standard deviation.
Results :
EM áreas - Central x Incisional: ECD: There are significant decrease at the incison area (p<0.001) and near CCI was 48% smaller than central area (Figure 1B and 2). CA: There are significant increase at the incision area (p<0.039) and near CCI was 101.5% higher than central area. CV: There are no significant changes at the incision area (p=0.981); HEX: There are no significant changes at the incision area (p=0.904).
EM áreas - Central x Nasal: ECD: There are significant increase at nasal area (p=0.039) and at the most distant EM from CCI was 6.2% higher than central area (Figure 1B and 2). CA: There are significant decrease at nasal area (p<0.037) and 4.6% smaller than central area. CV: There are significant increase at the nasal area (p<0.001); HEX: There are significant decrease at the nasal area (p=0.039).
Conclusions :
There are EM cells changes many years after PHACO + IOL surgery at the clear cornea incision: ECD 48% smaller and CA 101.5% higher relatively to the central area. The nasal peripheral area of the endothelial mosaic remains as expected.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.