July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Agreement between eyes and correlation of structural and functional data in patients with Usher Syndrome-associated retinitis pigmentosa
Author Affiliations & Notes
  • Marco Nassisi
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France, Paris, Ile de France, France
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, 28 rue de Charenton, F-75012 Paris, France, Paris, Ile de France, France
  • Saddek Mohand-Saïd
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France, Paris, Ile de France, France
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, 28 rue de Charenton, F-75012 Paris, France, Paris, Ile de France, France
  • Céline Devisme
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, 28 rue de Charenton, F-75012 Paris, France, Paris, Ile de France, France
  • Charlène Da Silva
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, 28 rue de Charenton, F-75012 Paris, France, Paris, Ile de France, France
  • Crystel Bonnet
    INSERM UMRS 1120, Institut de la Vision, Paris, France, Paris, Ile de France, France
  • Christina Zeitz
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France, Paris, Ile de France, France
  • Sandrine Marlin
    Centre de référence des Surdités Génétiques, Service de Génétique, APHP Hôpital Necker, Paris, France, Paris, France
  • Christine Petit
    INSERM UMRS 1120, Institut de la Vision, Paris, France, Paris, Ile de France, France
    Unité de Génétique et Physiologie de l’Audition, Institut Pasteur, Paris, France, Paris, France
  • Bahram Bodaghi
    Hôpital Pitié-Salpêtrière, 47-83, boulevard de l'hôpital, 75013 Paris, France, Paris, France
  • Jose Alain Sahel
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France, Paris, Ile de France, France
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, 28 rue de Charenton, F-75012 Paris, France, Paris, Ile de France, France
  • Isabelle S Audo
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France, Paris, Ile de France, France
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC1423, 28 rue de Charenton, F-75012 Paris, France, Paris, Ile de France, France
  • Footnotes
    Commercial Relationships   Marco Nassisi, None; Saddek Mohand-Saïd, None; Céline Devisme, None; Charlène Da Silva, None; Crystel Bonnet, None; Christina Zeitz, None; Sandrine Marlin, None; Christine Petit, None; Bahram Bodaghi, None; Jose Sahel, None; Isabelle Audo, None
  • Footnotes
    Support  This work was performed in the frame of the RHU LIGHT4DEAF [ANR-15-RHU-0001] supported by French state funds managed by the ANR within the Investissements d’Avenir program (also supporting a clinical research fellowship for MN). The supporters had no role in study design, data collection and analysis
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4510. doi:
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      Marco Nassisi, Saddek Mohand-Saïd, Céline Devisme, Charlène Da Silva, Crystel Bonnet, Christina Zeitz, Sandrine Marlin, Christine Petit, Bahram Bodaghi, Jose Alain Sahel, Isabelle S Audo; Agreement between eyes and correlation of structural and functional data in patients with Usher Syndrome-associated retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4510.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : to assess the interocular variation and the correlation between structural and functional parameters by using optical coherence tomography (OCT) and microperimetry in subjects with Usher syndrome-associated retinitis pigmentosa (RP).

Methods : in this cross-sectional study, best corrected visual acuity (BCVA) and contrast sensitivity (CS) were assessed with ETDRS and Pelli-Robson charts respectively; mean retinal sensitivity (MRS) in the central 10 degrees was obtained using a customized 27-point grid. An OCT macular scan 20°x20° wide (97 horizontal B-scans) was centered to the fovea to obtain the macular volume (MV) and the central retinal thickness (CRT). The agreement between eyes was tested with the Bland-Altman method and here presented as relative interocular difference (RID) values (mean differences expressed as percentage of the mean values of all eyes). Correlations between age, structural and functional parameters were calculated using Generalized Estimating Equation.

Results : forty eyes of 20 patients (8 females, age: 38 ± 17.4 years [range: 15-72 years]) were included. Symmetry between eyes was demonstrated for all considered parameters: MV and CRT showed RID values of 2,3% and 1%; functional data had RID values of 4.2%, 3.4%, and 2.1% (MRS, BCVA, and CS respectively). No significant correlations were found between structural and functional parameters. However, age was significantly correlated with BCVA (coefficient [B] = 0.15, p=0.01), CS (B=-0.17, p<0.01), and MRS (B = -0.15 p<0.01), but not with OCT values.

Conclusions : in general, good interocular agreement exists in this cohort of patients with syndromic RP. Although no correlations were found between structural and functional parameters, functional decline seems to be evident with increasing age (similar to previous studies on non-syndromic RP). Further investigations with prospective data are needed to confirm these findings.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Bland-Altman plots showing the intereye agreement of the structural and functional parameters considered in the study

Bland-Altman plots showing the intereye agreement of the structural and functional parameters considered in the study

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