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Yong Un Shin, Heeyoon Cho, Mincheol Seong, Eun Hee Hong, Doo Roo Kim, Min Ho Kang; Changes in Retinal Vessel and Retinal Layer Thickness after Vitrectomy in Macula-off Retinal Detachment Using Swept-source Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4547.
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© ARVO (1962-2015); The Authors (2016-present)
To compare post-vitrectomy retinal vessel density and retinal layer thickness between eyes with macula-off and macula-on rhegmatogenous retinal detachment (RRD) using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA) and to identify OCTA factors associated with visual outcome.
We retrospectively reviewed 50 eyes that underwent pars plana vitrectomy with primary RRD. Eyes with macula-off and macula-on RRD were compared with healthy fellow eyes. Both OCT and OCTA were performed at 6 months after surgery and macula-off RRD group was divided into two subgroups according to the presence of outer retinal defect on OCT. The correlation between postoperative best corrected visual acuity (BCVA) at 6 months and SS-OCT and OCTA measurements were analyzed.
15 eyes with macula-off RRD and 11 eyes with macula-on RRD were included. In the macula-off RRD group, the central retinal thickness was significantly decreased at postoperative 6 months compared to the fellow eyes (221.5 ± 26.4 µm and 270.0 ± 35.8 µm, p<0.001). In the outer retinal defect group, choroidal capillary plexus (CCP) vessel density (VD) was significantly decreased compared to the fellow eyes (207.3 ± 26.8 and 249.1 ± 40.5, p=0.018). Inner retinal thickness and superior and deep retinal capillary plexus VD did not show significant difference between detached eyes and fellow eyes in all groups. In the macula-off RRD group, the postoperative BCVA at 6 months was significantly correlated with the ratio of center CCP VD of the detached eyes to that of the fellow eyes (R2 =0.559, p=0.003).
The CCP VD may be related to anatomical restoration of the outer retinal layer in macula-off RD. CCP VD on OCTA may be one of OCTA marker to predict visual outcome after surgery of macula-off RD cases
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
Figure 1. Representative OCT images of two patients at 6 months after vitrectomy due to macula-off RRD. (A-C) a 60-year-old male patient. (A) OCT shows disruption of CIZ and EZ in an affected eye. In the OCTA, the central CCP VD in the affected eye (B) compared to that of the fellow eye (C). (D-F) a 55-year-old female pateint. (D) OCT show intact outer retinal layer in affected eye. In the OCTA image, the central CCP VD in affected eye (E) was similar to that of the fellow eye (F). Edit
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