July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Optical Coherence Tomography Angiography in Neonates with Retinopathy of Prematurity
Author Affiliations & Notes
  • Nikisha Kothari
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Mingyi Huang
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Fei Lin
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Benjamin Ray Lin
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Jennifer Pan
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Alex Huang
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Simon SM Fung
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Srinivas R Sadda
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Irena A Tsui
    UCLA Stein Eye Institute, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Nikisha Kothari, None; Mingyi Huang, None; Fei Lin, None; Benjamin Lin, None; Jennifer Pan, None; Alex Huang, None; Simon Fung, None; Srinivas Sadda, None; Irena Tsui, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4556. doi:https://doi.org/
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    • Get Citation

      Nikisha Kothari, Mingyi Huang, Fei Lin, Benjamin Ray Lin, Jennifer Pan, Alex Huang, Simon SM Fung, Srinivas R Sadda, Irena A Tsui; Optical Coherence Tomography Angiography in Neonates with Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4556. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To obtain optical coherence tomography angiography (OCTA) images of neonates with retinopathy of prematurity (ROP).

Methods : An observational consecutive case series was performed at a single hospital in the neonatal intensive care unit or operating room. Optical coherence tomography (OCT) and OCTA was performed under general anesthesia using the arm-mounted Spectralis Heidelberg Flex Module.

Results : Images were obtained in 10 eyes of 5 infants. All subjects were male with varying levels of ROP ranging from Stage 1 to Stage 4A treated with anti-VEGF, panretinal photocoagulation, and/or scleral buckling. The average gestational age was 25 weeks and 1 day; the average postmenstrual age was 43.7 weeks. There was an absent or small fovea avascular zone in all infants with retained inner retinal layers (Figure 1). Like adults, in infants with macular edema OCTA interpretation was limited (Figure 2).

Conclusions : OCTA has become widely used in adult retina practices; however, its utility and role in ROP is less understood. This feasibility study documents OCTA findings in infants with ROP of various stages. Additional studies are needed to assess the role of OCTA in studying ROP pathogenesis and the effects of ROP treatment.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

 

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