July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucoma Eyes.
Author Affiliations & Notes
  • Fernanda Mari Fagundes Fujihara
    Hospital Banco de Olhos de Porto Alegre, Porto Alegre, RS, Brazil
  • Paulo Augusto de Arruda Mello
    Department of Ophthalmology, Paulista School of Medicine, Federal University of São Paulo, Brazil
  • Camila Zanella Benfica
    Hospital de Clínicas de Porto Alegre, Brazil
  • Nedio Castoldi
    Hospital de Clínicas de Porto Alegre, Brazil
  • Fernanda Miranda Mendes
    Hospital de Clínicas de Porto Alegre, Brazil
    Department of Ophthalmology, Federal University of Rio Grande do Sul, Brazil
  • Rodrigo Leivas Lindenmeyer
    Hospital de Clínicas de Porto Alegre, Brazil
    Department of Ophthalmology, Federal University of Rio Grande do Sul, Brazil
  • Daniel Lavinsky
    Hospital de Clínicas de Porto Alegre, Brazil
    Department of Ophthalmology, Federal University of Rio Grande do Sul, Brazil
  • Helena Messinger Pakter
    Hospital de Clínicas de Porto Alegre, Brazil
    Ophthalmology, Hospital Nossa Senhora da Conceição, Brazil
  • Fabio Lavinsky
    Department of Ophthalmology, Paulista School of Medicine, Federal University of São Paulo, Brazil
    Hospital de Clínicas de Porto Alegre, Brazil
  • Footnotes
    Commercial Relationships   Fernanda Mari Fujihara, None; Paulo Augusto Mello, None; Camila Benfica, None; Nedio Castoldi, None; Fernanda Mendes, None; Rodrigo Lindenmeyer, None; Daniel Lavinsky, None; Helena Pakter, None; Fabio Lavinsky, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6144. doi:
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      Fernanda Mari Fagundes Fujihara, Paulo Augusto de Arruda Mello, Camila Zanella Benfica, Nedio Castoldi, Fernanda Miranda Mendes, Rodrigo Leivas Lindenmeyer, Daniel Lavinsky, Helena Messinger Pakter, Fabio Lavinsky; Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucoma Eyes.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6144.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The macular region is involved in the glaucomatous damage. Its parameters are useful for glaucoma diagnosis and monitoring. The aim of this study is to evaluate the individual macular layers using the automated segmentation of a commercially available device and its association with glaucoma and its severity.

Methods : Subjects with glaucoma presenting typical optic nerve head (ONH) findings, high intraocular pressure with or without visual field (VF) damage and normal controls were included. Patients underwent 24-2 perimetry (SITA standard; Humphrey Field Analyzer; Zeiss) and spectral-domain OCT (Spectralis; Heidelberg Engineering). Subjects were divided into three groups based on the severity (early, moderate and severe) of the mean deviation (MD) of the VF: ≥-6 dB; ≥-12 dB and <-12 dB, respectively; and a healthy control group. Automated individual layers and the summation of layers were checked for proper segmentation and plotted using the average of the sectors from the ETDRS Grid circles (diameters: center 1mm, inner circle 3mm, outer circle 6mm). Statistical analysis was performed using generalized estimating equations to allow for clustered observations.

Results : 109 eyes (67 subjects) qualified for the study. The mean age was 65.65±12.61. The number of eyes in each group was: 14 in the control group; 52, 18 and 25 in the early, moderate and severe glaucoma groups respectively. The overall difference between the groups was significant for the following parameters: MD; Visual Field Index (VFI); retinal nerve fiber layer (RNFL); and for both inner and outer circles of the ETDRS macular grid: total macular thickness, ganglion cell layer (GCL), inner plexiform layer (IPL), GCIPL, GCIPL+RNFL (table 1). The inner nuclear layer presented a significant difference between groups in both inner and outer circles. The outer nuclear layer differences were significant only in the inner circle (table 2).

Conclusions : Individual macular layer evaluation using the commercially available SD-OCT segmentation and the areas of the ETDRS grid could be used to evaluate different stages of glaucoma. Longitudinal studies of these parameters are needed to determine their usefulness for glaucoma monitoring.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

 

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