July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Fundus autofluorescence in premature infants
Author Affiliations & Notes
  • Yurico Lopez
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Ana Gonzalez-H.Leon
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Santiago Soberón
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Selene Rodríguez
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Luis Daniel Garcia Arzate
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Anri Pérez-Nakano
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Jazmin Baca Moreno
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Elsa Cynthia Hernández Piñamora
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Enrique Garcia
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Vanessa Tirado
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Karen Jazmín Herrera-Juárez
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Gerardo García-Aguirre
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Virgilio Morales-Canton
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Hugo Quiroz-Mercado
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Guillermo Salcedo- Villanueva
    Retina, Asociación Para Evitar la Ceguera en México, IAP, Mexico City, Mexico
  • Footnotes
    Commercial Relationships   Yurico Lopez, None; Ana Gonzalez-H.Leon, None; Santiago Soberón, None; Selene Rodríguez, None; Luis Daniel Garcia Arzate, None; Anri Pérez-Nakano, None; Jazmin Baca Moreno, None; Elsa Hernández Piñamora, None; Enrique Garcia, None; Vanessa Tirado, None; Karen Herrera-Juárez, None; Gerardo García-Aguirre, None; Virgilio Morales-Canton, None; Hugo Quiroz-Mercado, None; Guillermo Salcedo- Villanueva, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1560. doi:
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      Yurico Lopez, Ana Gonzalez-H.Leon, Santiago Soberón, Selene Rodríguez, Luis Daniel Garcia Arzate, Anri Pérez-Nakano, Jazmin Baca Moreno, Elsa Cynthia Hernández Piñamora, Enrique Garcia, Vanessa Tirado, Karen Jazmín Herrera-Juárez, Gerardo García-Aguirre, Virgilio Morales-Canton, Hugo Quiroz-Mercado, Guillermo Salcedo- Villanueva; Fundus autofluorescence in premature infants. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1560.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe fundus autofluorescence (FAF) patterns in newborn patients taken with an ultra-widefield laser ophthalmoscope.

Methods : Retrospective, descriptive case series of infants who were screened for retinopathy of prematurity (ROP). We included cases where ROP required observation only (Zone III, Stage 1 or 2), and had FAF images available. Evaluation of the images was done by two retina specialists in a blind manner. Images were graded in a dichotomic fashion (yes/no) according to the following parameters:
Presence or not of FAF, in general?
Optic nerve hypoautofluorescence visible?
Foveal hypoautofluorescence visible?
Peripapillary vessels hypoautofluorescence visible?
Equatorial vessels hypoautofluorescence visible?

Results : Fourteen patients from 36 to 62 weeks of corrected gestational age were included. In younger infants very poor fundus autofluorescence was noted, with barely visible contrast between the retina and blood vessels (peripapillary vessels visible in 78.6% of cases, with 48.5 weeks of mean corrected age, and equatorial vessels vissible in 42.8% of cases with 56.6 weeks of mean corrected age), poor foveal distinction was found as well (visible in 42.8% of cases with 49 weeks of mean corrected age). We found a positive correlation between visibility of posterior pole structures and increasing age. Migration of fluorophores following the retinal vascularization was seen, expanding in an eccentric pattern starting from the optic nerve.

Conclusions : It is possible to obtain and describe FAF patterns using ultra-widefield images in infants. FAF increases with age. Different hypoautofluorescent structures become visible throughout the first weeks/months.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Right eye. Male patient born at 26 weeks of gestation, with 860 grams of weight. He was 51 weeks of corrected age at evaluation. FAF image: hyperfluorescence in a radial fashion surrounding the optic nerve, peripapillary vessels are easily delineated.

Right eye. Male patient born at 26 weeks of gestation, with 860 grams of weight. He was 51 weeks of corrected age at evaluation. FAF image: hyperfluorescence in a radial fashion surrounding the optic nerve, peripapillary vessels are easily delineated.

 

Right eye. Male born at 26 weeks of gestation weighting 940 grams. He was 54 weeks of corrected age at evaluation. FAF image: hyperautofluorescence through all the retina mainly at the posterior pole, no normal hypoautofluroescence in the macular area is seen. Vessels can be identified easily due to contrast between hyperautofluorescent structures/vessels.

Right eye. Male born at 26 weeks of gestation weighting 940 grams. He was 54 weeks of corrected age at evaluation. FAF image: hyperautofluorescence through all the retina mainly at the posterior pole, no normal hypoautofluroescence in the macular area is seen. Vessels can be identified easily due to contrast between hyperautofluorescent structures/vessels.

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