July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Pattern Electroretinogram P50 to N95 Amplitude Compared with Spectral-Domain Optical Coherence Tomography Macular Parameters in Normal and Glaucoma Eyes
Fabio Lavinsky; Nedio Castoldi; Fernanda Mari Fagundes Fujihara; Jaco Lavinsky; Rodrigo Leivas Lindenmeyer; Camila Zanella Benfica; Daniel Lavinsky; Helena Messinger Pakter; Paulo Augusto de Arruda Mello
Author Affiliations & Notes
  • Fabio Lavinsky
    Department of Ophthalmology, São Paulo Hospital, Paulista School of Medicine, São Paulo, São Paulo, Brazil
    Department of Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil, Rio Grande do Sul, Brazil
  • Nedio Castoldi
    Department of Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil, Rio Grande do Sul, Brazil
  • Fernanda Mari Fagundes Fujihara
    Department of Ophthalmology, Hospital Banco de Olhos, Porto Alegre, Rio Grande do Sul, Brazil
  • Jaco Lavinsky
    Department of Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil, Rio Grande do Sul, Brazil
    Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
  • Rodrigo Leivas Lindenmeyer
    Department of Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil, Rio Grande do Sul, Brazil
    Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
  • Camila Zanella Benfica
    Department of Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil, Rio Grande do Sul, Brazil
  • Daniel Lavinsky
    Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Department of Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil, Rio Grande do Sul, Brazil
  • Helena Messinger Pakter
    Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Department of Ophthalmology, Hospital Nossa Senhora da Conceição, Brazil, Rio Grande do Sul, Brazil
  • Paulo Augusto de Arruda Mello
    Department of Ophthalmology, São Paulo Hospital, Paulista School of Medicine, São Paulo, São Paulo, Brazil
  • Footnotes
    Commercial Relationships   Fabio Lavinsky, None; Nedio Castoldi, None; Fernanda Mari Fujihara, None; Jaco Lavinsky, None; Rodrigo Lindenmeyer, None; Camila Benfica, None; Daniel Lavinsky, None; Helena Pakter, None; Paulo Augusto Mello, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2445. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Pattern Electroretinogram P50 to N95 Amplitude Compared with Spectral-Domain Optical Coherence Tomography Macular Parameters in Normal and Glaucoma Eyes
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Fabio Lavinsky, Nedio Castoldi, Fernanda Mari Fagundes Fujihara, Jaco Lavinsky, Rodrigo Leivas Lindenmeyer, Camila Zanella Benfica, Daniel Lavinsky, Helena Messinger Pakter, Paulo Augusto de Arruda Mello; Pattern Electroretinogram P50 to N95 Amplitude Compared with Spectral-Domain Optical Coherence Tomography Macular Parameters in Normal and Glaucoma Eyes. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2445.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose : This study aims to evaluate the pattern electroretinogram P50 to N95 amplitude (PERG), an objective functional parameter, and compare it to the macular parameters of the Spectral-Domain Optical Coherence Tomography (SD-OCT) in normal controls and glaucomatous eyes.

Methods : Subjects with glaucoma presenting typical optic nerve head (ONH) findings, high intraocular pressure with or without visual field (VF) damage and normal controls were included. Patients underwent 24-2 perimetry (SITA standard; Humphrey Field Analyzer; Zeiss), SD-OCT (Spectralis; Heidelberg Engineering) and PERG (Roland Consulttm). PERG was performed with 100% of contrast, reverse pattern in black-and-white with stimulus height of 4 cm. Automated individual layers and the summation of layers from the SD-OCT were checked for proper segmentation and plotted using the average of the sectors from the ETDRS Grid circles (diameters: center 1mm, inner circle 3mm, outer circle 6mm). Statistical analysis was performed using generalized estimating equations to allow for cluster observations and Spearman Rho for correlations.

Results : 72 eyes (45 subjects) qualified for the study. The mean age was 64.4±14.5. The number of eyes in each group was: 11 in the control group and 61 in the glaucoma group respectively. Controls and glaucomatous eyes had significantly different PERG, mean deviation (MD), retinal nerve fiber layer (RNFL) and parameters from inner retina, except for inner nuclear layer (table 1). MD, RNFL and macular parameters, except for inner nuclear layer (outer ETDRS grid circle) and outer plexiform layer (inner and outer ETDRS grid circles), were significantly associated with PERG (table 2).

Conclusions : Objective functional evaluation with PERG demonstrated to be significantly associated with the inner layers of the macula measured with SD-OCT. These layers are usually involved in glaucomatous neurodegenerative damage. Longitudinal studies evaluating the structure-function correlation between these parameters are needed to determine their impact on glaucoma clinical decisions.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Table 1
View OriginalDownload Slide

Table 1

Table 1

Table 1
View OriginalDownload Slide
 
Table 2
View OriginalDownload Slide

Table 2

Table 2

Table 2
View OriginalDownload Slide

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Attribution-NonCommercial-NoDerivatives
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept