July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Detection of Clinically Unsuspected Retinal Neovascularization with Wide-Field Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Qisheng You
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Yukun Guo
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Jie Wang
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Xiang Wei
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Acner Camino
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Pengxiao Zang
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Christina J Flaxel
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Steven T Bailey
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • David Huang
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Thomas S Hwang
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Yali Jia
    Casey Eye Institute, OHSU, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Qisheng You, None; Yukun Guo, None; Jie Wang, None; Xiang Wei, None; Acner Camino, None; Pengxiao Zang, None; Christina Flaxel, None; Steven Bailey, None; David Huang, Optovue, Inc. (F), Optovue, Inc. (I), Optovue, Inc. (P); Thomas Hwang, None; Yali Jia, Optovue, Inc. (F), Optovue, Inc. (P)
  • Footnotes
    Support  R01 EY027833, DP3 DK104397, R01 EY024544, P30 EY010572 from the National Institutes of Health (Bethesda,MD), and an unrestricted departmental funding grant and William & Mary Greve Special Scholar Award from Research to Prevent Blindness (New York, NY).
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3278. doi:
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    • Get Citation

      Qisheng You, Yukun Guo, Jie Wang, Xiang Wei, Acner Camino, Pengxiao Zang, Christina J Flaxel, Steven T Bailey, David Huang, Thomas S Hwang, Yali Jia; Detection of Clinically Unsuspected Retinal Neovascularization with Wide-Field Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3278.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate wide-field optical coherence tomography angiography for detection of clinically unsuspected retinal neovascularization in diabetic retinopathy.

Methods : This prospective observational single center study included adult patients with a clinical diagnosis of nonproliferative diabetic retinopathy. Participants underwent a clinical examination, standard 7-field color photography, optical coherence tomography angiography with commercial and prototype swept-source devices. The wide-field optical coherence tomography angiography was achieved by montaging five 6x10-mm scans from a prototype device into a 25 x10-mm image and three 6x6-mm scans from a commercial device into a 15x6-mm image. A masked grader determined the retinopathy severity from color photographs. Two trained readers examined conventional and the wide-field optical coherence tomography angiography images for the presence of neovascularization.

Results : Of 27 participants, photographic grading found 13 mild, 7 moderate, and 7 severe nonproliferative diabetic retinopathy. Conventional 6x6mm optical coherence tomography angiography detected retinal neovascularization in 2 eyes (7%) and none with 3x3-mm scans. (Figure 1) Both prototype and commercial wide-field optical coherence tomography angiography detected retinal neovascularization in 2 additional eyes. (Figure 2) The mean area of neovascularization was 0.38 mm2 (range 0.17 - 0.54 mm2). All eyes with optical coherence tomography angiography detected retinal neovascularization were photographically graded as severe nonproliferative diabetic retinopathy.

Conclusions : Wide-field optical coherence tomography angiography can detect small retinal neovascularization not seen on clinical examination or color photographs and may improve the clinical evaluation of diabetic retinopathy.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

 

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