Abstract
Purpose :
Our goal is to configure and validate the use of a portable device to perform quantitative pupillometry. A portable pupillometer might be useful in the clinic and in the research setting for diagnosis and monitoring of optic neuropathies and neurological disease.
Methods :
Light stimulation and pupil recording protocols were implemented using the retEVAL device (LKC Technologies Inc) using the Lua programming language following those used by Park et al (IOVS 2011) including manipulation of duration and intensity of blue light flashes. Full protocols were completed in 1 eye of 2 control subjects. In addition response to a 1-sec bright blue (316.2 cd/m2) flash following 3 minutes of dark adaptation was recorded in both eyes of two subjects with unilateral chronic optic neuropathies with clinically detectable relative afferent pupillary defects on clinical exam. Maximum pupillary constriction (1s after stimulus onset) and the post-illumination pupillary response (6-8s after stimulus onset) were extracted.
Results :
For control subjects the pupil response curves for different intensities and duration of blue light stimuli were similar to those reported by Park et al. Following 1s flashes of 316 cd/m2 blue light maximum constriction was 53%, 55% in control subjects, 26.9%, 29.3% in affected eyes and 37.9%, 52.23% in unaffected eyes and PIPR were 19.5%, 36.3% in the control subjects, 17%, 8.6% in the affected eyes and 19%, 16% in the unaffected eyes.
Conclusions :
The portable pupilometer measured maximum constriction to a 1s bright blue stimulus to be reduced in eyes with optic neuropathy compared with fellow eyes and control subject eyes. This provides initial validation for our portable pupilometer. Additional studies are needed to establish the normal range of responses and the clinical role in diagnosis and monitoring.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.