July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Electroretinography and Visual Function among Individuals Infected with Human Immunodeficiency Virus
Author Affiliations & Notes
  • Davin Carlton Ashraf
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Leticia Dourado Alves
    Department of Ophthalmology, Universidade Federal de Goiás, Goiânia, Brazil
  • Alla Kukuyev Goldberg
    Department of Ophthalmology, University of Texas Health Science Center of Houston, Houston, Texas, United States
  • Gary N Holland
    Department of Ophthalmology, UCLA Stein Eye Institute, Los Angeles, California, United States
    Ocular Inflammation Disease Center, UCLA Stein Eye Institute, Los Angeles, California, United States
  • Fei Yu
    Department of Ophthalmology, UCLA Stein Eye Institute, Los Angeles, California, United States
  • Steven Nusinowitz
    Department of Ophthalmology, UCLA Stein Eye Institute, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Davin Ashraf, None; Leticia Alves, None; Alla Goldberg, None; Gary Holland, None; Fei Yu, None; Steven Nusinowitz, None
  • Footnotes
    Support  1) Unrestricted grant from Research to Prevent Blindness, Inc. to UCLA Stein Eye Institute 2) Skirball Foundation
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 875. doi:
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    • Get Citation

      Davin Carlton Ashraf, Leticia Dourado Alves, Alla Kukuyev Goldberg, Gary N Holland, Fei Yu, Steven Nusinowitz; Electroretinography and Visual Function among Individuals Infected with Human Immunodeficiency Virus. Invest. Ophthalmol. Vis. Sci. 2019;60(9):875.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Individuals infected with human immunodeficiency virus (HIV) can have abnormalities of visual function (visual field, contrast sensitivity, color vision) and loss of retinal nerve fiber layer despite normal best corrected visual acuity (BCVA) and fundus appearance, a condition termed HIV-associated neuroretinal disorder (NRD). To characterize visual function in these individuals, we performed a cross-sectional study comparing electroretinography (ERG) of HIV-infected and normal individuals, and among the HIV cohort, compared visual function measures to selected ERG findings.

Methods : Included were 20 HIV-infected individuals (mean age 51.6±5.0) without infectious retinitis and 44 normal controls (mean age 39.9±13.0). Full-field (ffERG) and pattern ERGs (pERG) were recorded according to International Society for Clinical Electrophysiology of Vision standards. The HIV cohort underwent the following testing: BCVA, color discrimination (Lanthony Desaturated D-15), contrast sensitivity (Pelli Robson), and Humphrey visual field (HVF). Statistical analysis was performed with age-adjusted multiple linear regressions and Pearson correlations, using the mean of individuals' right and left eyes (no significant differences were found between the two eyes).

Results : The HIV cohort demonstrated small but significant reductions in response amplitudes and significant timing delays for most ffERG peak components. Rod- and cone- mediated function was affected approximately equally. The b-/a-wave amplitude ratio derived from the dark-adapted maximal response was not significantly different between cohorts. The HIV cohort demonstrated small but significant reductions in pERG amplitude (P50 and N95) with relative preservation of timing. The N95-/P50-wave amplitude ratios were not significantly different between cohorts. Cone b-wave amplitude was significantly correlated with HVF mean deviation (MD) and pERG peak component amplitude and timing were significantly correlated with BCVA and HVF-MD.

Conclusions : HIV-infected individuals without infectious retinitis can have retinal dysfunction despite normal fundus appearance and good visual function by clinical measures. Preserved b-/a-wave amplitude ratio suggests an outer retinal origin of the dysfunction. Although reduced pERG responses may implicate dysfunction of retinal ganglion cells, this may also result from reduced inputs to these cells from macular cones.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

 

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