July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Comparing Digital Cone-Contrast Threshold assessment in Healthy Normal Individuals with Conventional Standardized Color Vision Diagnostics
Author Affiliations & Notes
  • Clara Yuh
    College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Claremont, California, United States
  • Caroline Frambasch
    University of California Irvine, School of Medicine, California, United States
  • John Doan
    Medical College of Wisconsin, Wisconsin, United States
  • Kayla White
    University of California Irvine, School of Medicine, California, United States
  • Yanjun Chen
    Ophthalmology, Gavin Herbert Eye Institute, California, United States
  • Cristina Kenney
    Ophthalmology, Gavin Herbert Eye Institute, California, United States
  • Kimberly Jameson
    Ophthalmology, Gavin Herbert Eye Institute, California, United States
  • Andrew Browne
    Ophthalmology, Gavin Herbert Eye Institute, California, United States
  • Footnotes
    Commercial Relationships   Clara Yuh, None; Caroline Frambasch, None; John Doan, None; Kayla White, None; Yanjun Chen, None; Cristina Kenney, None; Kimberly Jameson, None; Andrew Browne, None
  • Footnotes
    Support  KL2 TR001416
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1319. doi:https://doi.org/
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      Clara Yuh, Caroline Frambasch, John Doan, Kayla White, Yanjun Chen, Cristina Kenney, Kimberly Jameson, Andrew Browne; Comparing Digital Cone-Contrast Threshold assessment in Healthy Normal Individuals with Conventional Standardized Color Vision Diagnostics. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1319. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Visual defects related to ocular diseases, such as diminished vision in dim lightning in patients with age-related macular degeneration (AMD), can manifest in the early phases of disease before visual acuity is even affected. Abnormalities of color perception have been identified in patients with early AMD; it has also been shown that testing color perception of early AMD patients can identify alterations in the retina. [REF: Dimitrov PN, Robman LD, Varsamidis M et al. Visual function tests as potential biomarkers in age-related macular degeneration. Invest Ophthalmol Vis Sci 2011; 52: 9457-9469.]
To identify and develop treatments before visual loss occurs, reliable functional standardized measures are required. To meet this need, we evaluated Cone Contrast Thresholds (CCT) to quantify cone-specific contrast sensitivity in healthy normal subjects and compared CCT results with conventional diagnostic measures.

Methods : A prospective study was performed on healthy normal subjects to evaluate their color visual function. 18 participants (36 eyes) were included based on normal medical and family history and normal fundoscopic examination. Subject consent, history, visual acuity, intraocular pressure, refractive error, and eye dominance were documented. Participants were subjected to color visual function tests of each eye in randomized order. Tests included: Cone Contrast Threshold under 6 conditions with testing in triplicate (non-mydriatic, mydriatic, with use of pinholes, and neutral density filters 03, 09, and 15), Ishihara Pseudoisochromatic Color Plates, Farnsworth-Munsell 100-hue Test color arrangement, and Neitz anomaloscope.

Results : The CCT assessment measures found changes from observed baseline (control) under conditions employing filtered lenses, pinholes, and dilated eyes. Significant reduction in CCT sensitivity values were found for patients who were dilated or using pinholes, and in patients using neutral density filters.

Conclusions : This study supports the utility and feasibility of employing CCT to examine patients during standard care to obtain quantitative metrics of color vision function. CCT is a reliable and quantitative tool for evaluating color visual function as compared to conventional diagnostic measures. CCT should only be employed in the undilated state and pinholes should not be used to correct for refractive error.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

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