Abstract
Purpose :
To report on the morphology of epiretinal membranes on a small cohort studied with adaptive optics scanning light ophthalmoscopy (AOSLO) and optical coherence tomography (OCT).
Methods :
Six patients (3 females, 3 males) diagnosed with epiretinal membranes (ERMs) were enrolled. Mean age (±SD) was 67±10 years (range 48-77). Retinal OCT (Cirrus, Carl Zeiss Meditec, Dublin, CA) and best corrected visual acuity (BCVA) data, obtained within 6 months as part of routine clinical care, were analyzed for this study. Simultaneous confocal and non–confocal split-detection AOSLO image sequences (Reflectance; λ=790 nm) as well as OCT angiography (OCTA; Optovue, Fremont, CA) macular scans were acquired (5 scans/eye). The en face OCTA images were registered and averaged using ImageJ. Registered and averaged AOSLO image sequences were montaged then manually co-registered to the OCTA images using Adobe Photoshop (Adobe Systems, Inc., San Jose, CA). One subject had follow-up AOSLO imaging two weeks after the initial visit.
Results :
Mean BCVA for 12/12 eyes was 20/30 (after converting to LogMAR). Mean central subfield thickness on OCT for 10/12 eyes was 318.8 ± 63.6 μm; which was significantly higher than previously reported normative mean; 262.4 ± 22.8 μm (t (200) = 6.676, p < 0.0001). On OCTs, epiretinal membranes were found in the macular area of 8/12 eyes, one eye had trace ERM post peel (Right eye of Subject 1; Table 1). Both en face OCTA and split detection AOSLO displayed macrofolds at the inner retinal interface in eyes with ERMs mostly centripetally arranged. Additionally, confocal AOSLO revealed surface texture details with highly hyper- and hypo-reflective features (Figure 1). Short term longitudinal follow-up on AOSLO on Subject 6 revealed changes in topographic morphology.
Conclusions :
High resolution AOSLO enables microscopic views of the topography of ERMs well below the resolution and sampling of commercially available OCT instruments. This technology might provide insights into the progression and development of ERMs.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.