July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Validation of the Icare® TONOVET Plus rebound tonometer in normal rabbit eyes
Author Affiliations & Notes
  • Julie Ann Kiland
    Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Abby Rothering
    Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Shawna Gloe
    Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Gillian J McLellan
    Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
    Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Footnotes
    Commercial Relationships   Julie Kiland, None; Abby Rothering, None; Shawna Gloe, None; Gillian McLellan, ICare (F)
  • Footnotes
    Support  Research to Prevent Blindness
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2427. doi:
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    • Get Citation

      Julie Ann Kiland, Abby Rothering, Shawna Gloe, Gillian J McLellan; Validation of the Icare® TONOVET Plus rebound tonometer in normal rabbit eyes. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2427.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the accuracy and precision of the Icare® TONOVET Plus (Icare Oy, Finland), an updated model of the TONOVET®, in normal rabbits.

Methods : The anterior chambers of both eyes of 3 young, adult New Zealand White rabbits (n=6 eyes) were cannulated in situ within 5 hours post-mortem. Manometric IOP was initially set at 5 mmHg and then increased in 5 mmHg increments to 40 mmHg and then in 10 mmHg increments to 70 mmHg, by raising the height of a fluid reservoir. Triplicate instrument-derived IOP values obtained at each increment using the TONOVET Plus® (rabbit setting) were compared to manometrically set IOPs and to IOPs obtained with 3 other commercially available handheld tonometers: the original TONOVET® (‘d’ setting), Tono-Pen Vet™, and Tono-Pen Avia™. Data were analyzed by linear regression; ANOVA followed by Tukey post-tests, and Bland-Altman plots. A p-value ≤0.05 was considered statistically significant.

Results : All tonometers showed linear trends when plotted against manometric IOP, but IOP values obtained in rabbit eyes using the TONOVET Plus® were significantly more accurate compared to those obtained with the TONOVET®, Tono-Pen Vet™, and Tono-Pen Avia™ (p<0.0001, p<0.0001, p<0.05, respectively). No significant differences in precision were found when comparing the TONOVET Plus® to the TONOVET® or Tono-Pen Vet™, however, both the TONOVET Plus® and the TONOVET® were significantly more precise than the Tono-Pen AVIA™ (p<0.05). All tonometers tended to underestimate IOP, though magnitude of this underestimation was far less with the TONOVET Plus® (Figure 1).

Conclusions : TONOVET Plus®, which incorporates a species-specific calibration setting for rabbits, provided accurate and precise IOP values in rabbits, particularly in the clinically relevant range of 5-50 mmHg. The TONOVET Plus® represents a significant improvement in accuracy over other commercially available tonometers when measuring IOP non-invasively in rabbits in research, toxicology and veterinary clinical settings. However, values obtained with the TONOVET Plus® and with its predecessor, the TONOVET, are not interchangeable.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Linear regression of IOPs obtained with the Icare® TONOVET Plus, TONOVET®, Tono-Pen Vet™, and Tono-Pen AVIA™ plotted against the manometric pressures. y=x line shown for reference of true pressures.

Linear regression of IOPs obtained with the Icare® TONOVET Plus, TONOVET®, Tono-Pen Vet™, and Tono-Pen AVIA™ plotted against the manometric pressures. y=x line shown for reference of true pressures.

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