Abstract
Purpose :
It has been shown that the IOP signal after the prior steroid is highly predictive of the intraocular pressure (IOP) response post FAc. However, studies have not generally provided detail on the relationship of IOP response to steroids administered following with 0.2 ug/day FAc. The current analysis looks at the IOP response in eyes that have received at least one supplemental ocular steroid injection after FAc.
Methods :
Retrospective chart review of 0.19 mg FAc-treated eyes that had supplemental ocular steroid injections after FAc to treat their DME. IOP was collected prior to the steroid challenge (as indicated by treating physician), and at various timepoints through the follow up period.
Results :
There were 65 eyes collected from chart reviews totaling 337 eyes (12 sites) that had at least one supplemental ocular steroid injection after FAc. 151 total supplemental steroid injections (79% dexamethasone, 13% triamcinolone acetonide, 8% FAc) were given (range 1-10). Mean follow up was 671 days (range 162-1265 days). Mean time to first supplemental steroid was 273 days post FAc implant. All eyes were treated per US label and had received a steroid challenge before FAc. Very few eyes had an IOP >25 mmHg post FAc despite the supplemental steroid injections further supporting the predictability of IOP response. Two patients had an IOP >30 mmHg after supplemental steroid and one required incisional surgery. Overall, the mean IOP change was < 3 mmHg over the follow-up period with up to 3 or more additional steroids. Of the 45 eyes that received one supplemental steroid post FAc, the mean IOP increase was 2 mmHg. Of the eyes that received two supplemental steroids, the mean IOP increase was 2mmHg. Of the eyes that received three supplemental steroids, the mean IOP increase was 2.5mmHg.
Conclusions :
The steroid challenge is predictive of the IOP response post FAc even in the limited set of eyes that required supplemental intraocular steroid.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.