July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Ocular Vessel Density Among Healthy Subjects of Different Ethnicities
Author Affiliations & Notes
  • Maria de los Angeles Ramos Cadena
    NYU Langone Health, NYU Eye Center, New York, New York, United States
  • Hiroshi Ishikawa
    NYU Langone Health, NYU Eye Center, New York, New York, United States
  • Joel Schuman
    NYU Langone Health, NYU Eye Center, New York, New York, United States
  • Katie Lucy
    NYU Langone Health, NYU Eye Center, New York, New York, United States
  • Mengfei Wu
    NYU Langone Health, NYU Eye Center, New York, New York, United States
    Division of Biostatistics, Department of Population Health and Environmental Medicine, NYU Langone Health, New York, New York, United States
  • Mengling Liu
    NYU Langone Health, NYU Eye Center, New York, New York, United States
    Division of Biostatistics, Department of Population Health and Environmental Medicine, NYU Langone Health, New York, New York, United States
  • Ravneet Singh Rai
    NYU Langone Health, NYU Eye Center, New York, New York, United States
  • Jesús Jiménez Román
    Glaucoma, Asociación Para Evitar la Ceguera en México I.A.P., CDMX, Ciudad de Mexico, Mexico
  • Gabriel Lazcano
    Glaucoma, Asociación Para Evitar la Ceguera en México I.A.P., CDMX, Ciudad de Mexico, Mexico
  • Daniela Díaz Robles
    Glaucoma, Asociación Para Evitar la Ceguera en México I.A.P., CDMX, Ciudad de Mexico, Mexico
  • Joong Won Shin
    Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Seoul, Korea (the Republic of)
    University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangneung, Korea (the Republic of)
  • Kyung Rim Sung
    Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Seoul, Korea (the Republic of)
  • Gadi Wollstein
    NYU Langone Health, NYU Eye Center, New York, New York, United States
  • Footnotes
    Commercial Relationships   Maria de los Angeles Ramos Cadena, None; Hiroshi Ishikawa, None; Joel Schuman, Zeiss (P); Katie Lucy, None; Mengfei Wu, None; Mengling Liu, None; Ravneet Rai, None; Jesús Jiménez Román, None; Gabriel Lazcano, None; Daniela Díaz Robles, None; Joong Won Shin, None; Kyung Rim Sung, None; Gadi Wollstein, None
  • Footnotes
    Support  R01-EY013178
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3065. doi:https://doi.org/
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    • Get Citation

      Maria de los Angeles Ramos Cadena, Hiroshi Ishikawa, Joel Schuman, Katie Lucy, Mengfei Wu, Mengling Liu, Ravneet Singh Rai, Jesús Jiménez Román, Gabriel Lazcano, Daniela Díaz Robles, Joong Won Shin, Kyung Rim Sung, Gadi Wollstein; Ocular Vessel Density Among Healthy Subjects of Different Ethnicities. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3065. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography angiography (OCTA) is an imaging technology that evaluates volumetric retinal vasculature, with a wide variety of applications. In this study we compared the ocular vessel density of healthy subjects among Caucasian, Asian, and Latin ethnicities.

Methods : Healthy subjects with normal comprehensive ophthalmic examination, qualified visual field (VF; Humphrey Field Analyzer; Zeiss, Dublin, CA), OCT (Cirrus HD-OCT Angioplex; Zeiss) optic nerve head (ONH) scans (200x200 ONH cube scan) and OCTA scans (3x3 OCTA ONH cube scans) were included. Subjects with comorbidities affecting the systemic or local micro or macro vasculature and subjects taking medications that modify vessel diameter were excluded. Peripapillary ocular vessel density (VD) was calculated using the device's native software. A univariable model was used to compare VD among ethnicities and a multivariable model was used to describe the associations between VD and cup volume (CV), cup to disc ratio, retinal nerve fiber layer (RNFL), signal strength (SS), and spherical equivalent (SE) refractive error. A mixed effects model was used to account for inter-and intra-subject correlations.

Results : 99 eyes of 66 healthy subjects (39 Caucasian, 46 Asian, and 14 Latin) were included in the study. SE was significantly different among ethnicities (p=0.003), but no significant association was detected with VD (Table). A significantly larger VD was observed in Caucasians vs Asians (p=0.008). No difference was observed in Caucasians vs Latins (p=0.09) or Asians vs Latins (p=0.92). For every mm3 increase of CV the VD decreased 6.93mm/mm2, being more significant in Latins (p=0.007). One unit increase of SS was associated with a 0.33mm/mm2 (p=0.013) of larger VD for all ethnicities. All other variables included in the model showed no association with VD.

Conclusions : VD is not the same among ethnicities. Among the included global parameters, CV is the only one associated with VD. The difference in VD among different ethnicities and its implications on pathophysiology of retinal diseases needs to be further explored. A normative database considering ethnicity differences should be established in order to include VD measurements in clinical evaluation.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Table. Demographic and clinical characteristics of healthy Caucasian, Asian, and Latin subjects

Table. Demographic and clinical characteristics of healthy Caucasian, Asian, and Latin subjects

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