July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Age-Related Optic Nerve Head and Retinal Microvasculature Dropout Varies by Race
Author Affiliations & Notes
  • Mohamad Moghadam
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Jason Han Lee
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Robert N Weinreb
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Rohith Voora
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Christopher Bowd
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • James Alexander Proudfoot
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Sasan Moghimi
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Rafaella Penteado
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Huiyuan Hou
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Elham Ghahari
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Patricia Manalastas
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Mark Christopher
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Akram Belghith
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Linda M Zangwill
    Glaucoma, Shiley Eye Institute, San Diego, California, United States
  • Footnotes
    Commercial Relationships   Mohamad Moghadam, None; Jason Lee, None; Robert Weinreb, Aerie Pharmaceuticals (C), Allergan (C), Bausch&Lomb (F), Carl Zeiss Meditec (F), Centervue (F), Eyenovia (C), Genentech (F), Heidelberg Engineering (F), Implantdata (C), Konan (F), Meditec-Zeiss (P), Optos (F), Optovue (F), Sensimed (C), Topcon (F), Toromedes (P), Unity (C), Valeant (C); Rohith Voora, None; Christopher Bowd, None; James Proudfoot, None; Sasan Moghimi, None; Rafaella Penteado, None; Huiyuan Hou, None; Elham Ghahari, None; Patricia Manalastas, None; Mark Christopher, None; Akram Belghith, None; Linda Zangwill, Carl Zeiss Meditec Inc (F), Heidelberg Engineering (R), Heidelberg Engineering GmbH (F), National Eye Institute (F), Optovue Inc. (F), Topcon Medical Systems Inc. (F)
  • Footnotes
    Support  EY11008, EY19869, EY14267, EY029058, EY027510, EY026574, EY029058, P30EY022589, EY027945, EY022039, EY023704, EY029058, T32EY026590, UCSD School of Medicine Summer Research Fellowship, and and participant retention incentive grants in the form of glaucoma medications at no cost from Novartis/Alcon Laboratories Inc, Allergan, Akorn, and Pfizer Inc. Unrestricted grant from Research to Prevent Blindness, New York, New York
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3066. doi:https://doi.org/
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      Mohamad Moghadam, Jason Han Lee, Robert N Weinreb, Rohith Voora, Christopher Bowd, James Alexander Proudfoot, Sasan Moghimi, Rafaella Penteado, Huiyuan Hou, Elham Ghahari, Patricia Manalastas, Mark Christopher, Akram Belghith, Linda M Zangwill; Age-Related Optic Nerve Head and Retinal Microvasculature Dropout Varies by Race. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3066. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine age-related differences in the pattern and distribution of microvasculature density and retinal tissue thickness in healthy eyes of individuals of African descent (AD) and European descent (ED).

Methods : OptoVue Avanti (optical coherence tomography angiography (OCTA) imaging) macula (3 x 3 mm2) and optic nerve head (ONH, 4.5 x 4.5 mm2) scans of 20 eyes of 12 individuals of AD and 77 eyes of individuals of 41 ED from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES) were included. Racial differences in whole image macula vessel density of the superficial and deep layer plexuses, whole image ONH capillary densities (CD after removal of the large vessels), global ganglion cell complex (GCC, excluding the fovea) and global circumpapillary retinal nerve fiber layer (cpRNFL) thickness of each eye were assessed using non-parametric clustered Wilcoxon signed-rank tests.

Results : Mean age was similar between AD and ED individuals [mean (95% CI: 58.9 (52.3, 62.3) and 58.9 (53.1, 64.8) years, respectively]. No significant racial differences were observed between any of the baseline vessel density or tissue thickness parameters investigated (all p ≥ 0.07). However, the age-related decrease of superficial layer macular vessel density, ONH vessel density, GCC thickness, and cpRNFL thickness per year was greater in individuals of AD compared to ED (all p≤0.050). Specifically, we found significant racial differences in age-related changes for superficial layer macular vessel density (AD: -0.25% and ED: 0.07% per year) and peripapillary capillary density (AD: -0.19% and ED: -0.02%) per year). Racial differences in age-related decrease in GCC (AD: -0.91µm and ED: -0.29 µm per year) and cpRNFL thickness (AD: -1.22µm and ED:-0.31 µm per year). Deep layer macula vessel density did not show significant racial difference in age-related changes.

Conclusions : Age-related decrease in superficial macular vessel density, ONH vessel density, cpRNFL, and GCC were greater in individuals of AD compared to ED. Further work is needed to determine whether these racial differences in age-related changes influence the higher the prevalence and incidence of glaucoma in individuals of AD. These data can also inform reference databases of vessel density measurements with respect to race.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

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