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Qinqin Zhang, Kasra Attaran-Rezaei, Ruikang K Wang; Ultra-wide field optical coherence tomography angiography for evaluation of retinal venous occlusion. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3280.
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To develop and demonstrate ultra-wide field OCT angiography (UW-OCTA) for imaging patients with retinal venous occlusion (RVO)
UW-OCTA was developed based on a 1060 nm swept source OCTA engine (PLEX® Elite 9000 (ZEISS, Dublin, CA)) running at 100 kHz A-line rate with motion tracking mechanism. A montage scanning protocol was designed to enable the UW-OCTA imaging, covering a field of view (FOV) of ~100 degrees. For the montaging scan, 2 cube scans were performed on each patient. Each cube scan covered 15×9 mmsampled by 834 A-lines × 500 B-frames with 2 repetitions at each B-scan location. Complex OMAG algorithm was used to extract blood flow information. To visualize retinal vasculature, two layers were segmented including superficial retinal layer (SRL) extending from ILM to IPL, deep retinal layer (DRL) from outer border of IPL to outer border of OPL, which were then color-coded to appreciate depth information. Branch retinal venous occlusion (BRVO) and central retinal venous occlusion (CRVO) patients were recruited and scanned to show the usefulness of the UW-OCTA in clinically imaging RVO patients
30 patients with BRVO/CRVO at different stages underwent UW-OCTA scans. In comparison with FA, UW-OCTA images provided more distinct and detailed visualization of vascular networks over ~100-degree FOV. Tortuous vessels have been observed both in BRVO and CRVO patients, and dilated vessels were clearly manifested in mild CRVO/BRVO on UW-OCTA images. In addition, the UW-OCTA images showed the macular ischemia and non-perfusion regions with high contrast compared with FA images. UW-OCTA images also provided detailed information of other vascular features, including microaneurysms, intra-retinal microvascular abnormalities (IRMA), and neovascularization. Representative examples from two patients are shown in Figs 1 and 2 along with FA images for comparison
The wide angle OCTA is capable of imaging peripheral retina vasculatures, comparable to that of wide-angle fundus image. We have successfully demonstrated the UW-OCTA of RVO patients that extends to more than 100-degree view angle and provides unprecedented vascular details in the peripheral regions. Further studies will be done to quantify OCTA both on normal and abnormal region and identify the starting region of occlusion
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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