July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Relative influences of clusters of individual characteristics, behavioral patterns and socio-economic status on the risk of age-related eye conditions
Author Affiliations & Notes
  • Simon Nusinovici
    Singapore Eye Research Institute, Singapore, Singapore
  • Liang Zhang
    Singapore Eye Research Institute, Singapore, Singapore
  • Miao Li Chee
    Singapore Eye Research Institute, Singapore, Singapore
  • Xiaoran Chai
    Singapore Eye Research Institute, Singapore, Singapore
  • Yih Chung Tham
    Singapore Eye Research Institute, Singapore, Singapore
  • Charumathi Sabanayagam
    Singapore Eye Research Institute, Singapore, Singapore
  • Tien Yin Wong
    Singapore Eye Research Institute, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Simon Nusinovici, None; Liang Zhang, None; Miao Li Chee, None; Xiaoran Chai, None; Yih Chung Tham, None; Charumathi Sabanayagam, None; Tien Wong, None; Ching-Yu Cheng, None
  • Footnotes
    Support  NMRC CIRG/1417/2015, CIRG/1488/2018, and OFLCG/004a/2018
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4451. doi:https://doi.org/
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      Simon Nusinovici, Liang Zhang, Miao Li Chee, Xiaoran Chai, Yih Chung Tham, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng; Relative influences of clusters of individual characteristics, behavioral patterns and socio-economic status on the risk of age-related eye conditions. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4451. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Few studies have examined the relative effects of risk factors for major age-related eye conditions, within the same population. The objective of this study was to investigate the relative influences of individual and ocular characteristics, metabolic profile, genetic background, behavioral patterns, and socio-economic status on the risk of visual impairment (VI), retinopathy, cataract, age-related macular degeneration (AMD) and glaucoma.

Methods : Cross-sectional population-based study comprised of 3,353 Chinese aged 40-80 years. The examined determinants included individual factors (age, gender), ocular characteristics (axial length, vessel calibers, intraocular pressure (IOP)), metabolic profile (>200 untargeted metabolites), genetic background (principal components extracted from >6,000,000 variants), behavioral patterns (smoking, body mass index, alcohol intake) and socio-economic status (educational level, job category, number of household, religion). The relative influences of each risk factor on the occurrence of VI and eye diseases were investigated using boosted regression trees, a machine learning approach that handles nonlinear effects and interactions. The relative influence of each factors within the same determinant cluster were then added together.

Results : The prevalence rates were 26.9% for VI, 7.9% for retinopathy, 34.0% for cataract, 8.0% for AMD, and 4.0% for glaucoma. In terms of relative influence, age was the main determinant for VI (32.2%), cataract (64.3%) and AMD (16.6%); diabetes was the main determinant for retinopathy (23.1%); and IOP was the main factor for glaucoma (20.9%) (Figure 1). By cluster, metabolic profile (52.6%) was the most important determinant for retinopathy, individual characteristics (64.3% and 32.4%) for cataract and VI, and ocular characteristics (39.1%) for glaucoma. (Figure 2). Finally, the relative influence of behavioral patterns was moderate for all conditions (3.3 to 10.9%).

Conclusions : There is heterogeneity in the determinants of the major eye conditions, which may help identify risk factors that could be targeted for preventive measures.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Relative influences of the main risk factors on the risk of age-related eye conditions

Relative influences of the main risk factors on the risk of age-related eye conditions

 

Relative influences of the cluster of determinants on the risk of age-related eye conditions

Relative influences of the cluster of determinants on the risk of age-related eye conditions

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