July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Healthy and pathological visual aging in a French follow-up cohort study
Author Affiliations & Notes
  • Karine LAGRENE
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
    Streetlab, Paris, France
  • Marcia Bécu
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
  • William H Seiple
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
    Lighthouse Guild, New York, New York, United States
  • Marine Raphanel Bataille
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
  • Sonia Combariza
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
  • Michel Paques
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, Paris, France
  • Anne Aubois
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, Paris, France
  • Bertrand Duclos
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, Paris, France
  • Chiara Eandi
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, Paris, France
  • Jean-François Girmens
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, Paris, France
  • Saddek Mohand-Said
    CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, Paris, France
  • Angelo Arleo
    Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
  • Footnotes
    Commercial Relationships   Karine LAGRENE, None; Marcia Bécu, None; William Seiple, None; Marine Raphanel Bataille, None; Sonia Combariza, None; Michel Paques, None; Anne Aubois, None; Bertrand Duclos, None; Chiara Eandi, None; Jean-François Girmens, None; Saddek Mohand-Said, None; Angelo Arleo, Essilor International (C)
  • Footnotes
    Support  ANR Grant 789 14-CHIN-0001
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5915. doi:
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    • Get Citation

      Karine LAGRENE, Marcia Bécu, William H Seiple, Marine Raphanel Bataille, Sonia Combariza, Michel Paques, Anne Aubois, Bertrand Duclos, Chiara Eandi, Jean-François Girmens, Saddek Mohand-Said, Angelo Arleo; Healthy and pathological visual aging in a French follow-up cohort study. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5915.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Visual aging leads to multiscale changes, from the structures of the eye to sensory transduction, neural transmission, and perception. Also, visuo-cognitive alterations impact visual perception, as demonstrated in divided-attention and visuo-spatial tasks. The French cohort study SilverSight assesses anatomic and functional changes induced by healthy and pathological visual aging, both cross-sectionally and longitudinally. The goal is to understand the relationships between retinal cellular changes (e.g., anatomical and physiological modifications measured with high-resolution adaptive optics retina imaging) and visual symptoms, to identify functional biomarkers of normal and pathological aging.

Methods : The SilverSight cohort targets a population of 400 voluntary participants: 350 healthy subjects and 50 AMD patients. Notably, all enrolled participants undergo a deep multidimensional screening (Figure 1), involving ophthalmological, visual, audio-vestibular, sensorimotor, cognitive, and neuropsychological examinations. We also administer a series of standardized questionnaires and patient-reported outcomes to quantify vision related quality of life and autonomy. All clinical and functional measures are conducted at the National Eye Hospital CHNO des Quinze-Vingts, Paris. The longitudinal follow-up of the SilverSight cohort study is done on a yearly basis.

Results : Since 2015, 364 subjects were screened. Healthy participants are distributed across 3 age groups: 18-40yo (N=140), 41-64yo (N=60), and >65yo (N=158). 25 early- and 25 intermediate-stage AMD patients, as defined by the AREDS grades 2-5 and grades 6-9 in the enrollment eye, are being screened. All data are centralized in a connected anonymized database (eCRF SilverSight), made available for multicenter cohort studies.

Conclusions : The multidimensional screening realized by the SilverSight follow-up cohort study provides a unique database to better understanding the impact of aging on vision and has the potential to uncover cross-causal functional signatures of pathogenic aging mechanisms.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Figure 1. Multidimensional clinical and functional measures assessed by the SilverSight cohort study.

Figure 1. Multidimensional clinical and functional measures assessed by the SilverSight cohort study.

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