July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
The ues of MRI 3D reconstruction of orbital tissue in dysthyroid optic neuropathy
Author Affiliations & Notes
  • Zhang Te
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
    Sun Yat-Sen University, Guangzhou, China
  • Yang huasheng
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
    Sun Yat-Sen University, Guangzhou, China
  • Footnotes
    Commercial Relationships   Zhang Te, None; Yang huasheng, None
  • Footnotes
    Support  Financial support: The National Natural Science Foundation of China (81470664, 81670887 and 81870689)
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6212. doi:
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      Zhang Te, Yang huasheng; The ues of MRI 3D reconstruction of orbital tissue in dysthyroid optic neuropathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6212.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To verify the accurity of a new MRI 3D reconstruction technology and evaluate the severity of dysthyroid optic neuropathy (DON) .

Methods : Using butter and chicken muscle, we simulated the orbital soft tissue and measured the their volume based on the MRI scan and 3D reconstruction software, the data were compared with the real volume gained by manual measurement. Then patients diagnosed as thyroid-associated ophthalmopathy (TAO) with or without DON, and healthy participants were recruited. All orbital fat and rectus of participants were measured by the MRI 3D reconstruction. Visual function, including visual best-corrected visual acuity (BCVA), visual field (VF) and visual evoked potential (VEP), were assessed for all TAO patients. Futhermore, we correlated the fat volume, rectus volume and the ratio of rectus and fat volume with the parameters of visual function.

Results : The intraclass correlation coefficient (ICC) between the 3D reconstruction data and real volume data of fat and muscle was 0.963 and 0.986. Compared with the healthy participants and the TAO patients without DON, the DON rectus volume of DON patients increased statistically significantly (P<0.05) and the ratio of rectus and fat was also increased (P<0.05). In TAO patients, the ratio were well correlated with BCVA (r=0.696) and mean defection of visual field (r=-0.601). Howerer, the fat volume and the rectus volume were not correlated with the visual function parameters significantly.

Conclusions : The new MRI 3D reconstruction technology can measure the orbital soft tissue precisely. DON patients have increased rectus volume and high ratio of rectus and fat. And the ratio would be a ideal parameters to evluate the severity of DON.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

the 3D reconstruction of butter and chicken muscle modles

the 3D reconstruction of butter and chicken muscle modles

 

The orbital MRI 3D reconstruction shows the orbital fat, eyeball, extraocular muscle and optic nerves.

The orbital MRI 3D reconstruction shows the orbital fat, eyeball, extraocular muscle and optic nerves.

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