July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Air-puff induced eye retraction and crystalline lens wobbling measured with long depth range swept source optical coherence tomography
Author Affiliations & Notes
  • Alfonso Jimenez-Villar
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
  • Ewa Maczynska
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
  • Jagoda Rzeszewska
    Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
  • Maciej Wojtkowski
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
    Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
  • Bartlomiej Jan Kaluzny
    Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
  • Ireneusz Grulkowski
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
  • Footnotes
    Commercial Relationships   Alfonso Jimenez-Villar, None; Ewa Maczynska, None; Jagoda Rzeszewska, None; Maciej Wojtkowski, None; Bartlomiej Kaluzny, None; Ireneusz Grulkowski, None
  • Footnotes
    Support  Polish National Science Center (#2014/14/E/ST7/00637; #2015/18/E/NZ5/00697), European Union’s Horizon 2020 (BE-OPTICAL; #675512); European Union’s Horizon 2020, Information and Communication Technologies (IMCUSTOMEYE; #779960); European Union’s Horizon 2020, research and innovation (CREATE; #666295).
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6822. doi:https://doi.org/
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      Alfonso Jimenez-Villar, Ewa Maczynska, Jagoda Rzeszewska, Maciej Wojtkowski, Bartlomiej Jan Kaluzny, Ireneusz Grulkowski; Air-puff induced eye retraction and crystalline lens wobbling measured with long depth range swept source optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6822. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze the impact of eye retraction on ocular structures deformations during air puff using full eye length SS-OCT data. To assess the impact of intraocular pressure on lens axial wobbling due to air-puff.

Methods : Twenty Caucasian healthy subjects (mean age 27.6±3.5 yo) were recruited. The mean spherical equivalent refractive error was -1.1±1.5D, with a mean K_ave of 43.6±1.7D, and mean cylinder -0.93±0.67D. The measurements were performed on a single eye of each subject. The subjects underwent full ophthalmic examination including slit lamp biomicroscopy and corneal topography. A prototype long depth range SS-OCT operating at 1µm wavelength and at a sweep rate of 30,000 A-scans/s, was integrated with a non-contact tonometer to image the entire eye length during air puff stimulus. The OCT data consisting of 4000 A-scans were acquired along the visual axis (measurement time 133 ms). The intraocular pressure (IOP) was assessed using Goldmann tonometer prior to the OCT scanning. The data set carried information on the dynamics of all ocular elements during air-puff and allowed to extract the eye retraction and lens wobbling amplitudes (Fig.1). The effects of eye retraction and lens wobbling were modelled using rheological model.

Results : Long-range SS-OCT along the visual axis enabled visualization of the eye dynamics during the air-puff stimulation with high temporal resolution. Significant statistical differences were found in corneal deformation amplitude (no correction=1.10±0.09mm; eye-retraction correction=0.89±0.23mm, p-value=0.0005), oscillatory lens wobbling amplitude (no correction=0.25±0.04mm; eye-retraction correction=0.10±0.04mm, p-value=0.0001) and corneal hysteresis (no correction=0.038±0.007µJ, eye-retraction correction=0.013±0.003µJ, p-value=0) when eye retraction correction was applied. This allowed also to obtain statistically significant correlation of those parameters with the IOP. Rheological model could characterize the observed effects (Fig.2).

Conclusions : Air-puff long-range SS-OCT allows determination of the eye retraction and correct time-dependent deformation profiles of all ocular structures. This provides access to axial lens wobbling effect, which is correlated with the IOP.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Fig.1 Deformation profiles. (a) Cornea. (b) Lens.

Fig.1 Deformation profiles. (a) Cornea. (b) Lens.

 

Fig.2 Rheological model predictions. (a) Eye retraction. (b) Cornea deformation. (c) Lens wobbling.

Fig.2 Rheological model predictions. (a) Eye retraction. (b) Cornea deformation. (c) Lens wobbling.

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