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Caleb Shumway, Karen Curtin, Sam Taylor, Chase Paulson, Barbara M Wirostko; Evaluation of Risk Factors for Pseudoexfoliation and Progression to Glaucoma: A Longitudinal Epidemiological Study. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1994.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the risk factors associated with pseudoexfoliation and progression to glaucoma.
Of 500 patients with pseudoexfoliation, a random sample of 26 patients were selected for this retrospective, chart review study. The patients had been seen between the years of 1980 to 2018. The patientshad been stratified according to their diagnosis of pseudoexfoliation and/or pseudoexfoliation glaucoma and were identified as either progressors, non-progressors, and regressors. The following parameters were collected for the purpose of our chart review: age, gender, age at first diagnosis of psuedoexfoliation or glaucoma, intraocular pressure (IOP), visual fields, C/D ratio, and global nerve fiber layer OCT. Comorbid ocular conditions and surgical or topical therapies were also documented. The results of the review were stratified by the diagnosis groups and reported within each cohort, then compared with each other via One-way ANOVA.
The overall mean intraocular pressure among all groups was 18.75 mmHg OD (+/- 7.71) and 18.86 OS (+/- 7.37). The C/D ratio mean was 0.51 OD (+/- 0.29) and 0.46 OS (+/- 0.19). The RNFL global mean was 82.31 OD (+/- 51.95) and 74.90 OS (+/- 18.22). When the groups were analyzed in terms of differences by One-way ANOVA, there was no statistical difference between groups.The most common comorbid ocular condition was cataract. The most common therapeutic surgical procedure was cataract extraction, followed by trabeculectomy.
Pseudoexfoliation is a complex clinical entity which has systemic implications. This study identified some of the risk factors associated with this disease, and may be useful for crafting future studies that analyze a larger patient population.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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