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Caiqing Wu, Ping Wai Or, Jones Chong, Xiaotao Chen, Ching Hymn Christopher Lee, Isuru KK Pathirage Don, Minbin Yu, David Lam, Yangfan Yang; Extended Delivery of Pirfenidone with Novel Soft Contact Lenses. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3804. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
A drug-loaded soft contact lens (SCL) for extended pirfenidone (PFD) delivery has been developed. The distribution over time and effects of sustained release were evaluated in rabbits.
A water-soluble insert, consisting of polyvinyl alcohol (PVA) and PFD, was embedded into a soft contact lens for extended delivery. Soft contact lenses were fitted to 4 New Zealand white rabbits weighing between 2.0kg to 2.5kg. The rabbits wore SCLs for 24 continuous hours while monitoring the irritation using the Draize score system. The safety of the SCL was evaluated on the eye surface performance by slit-lamp microscopic examination in vivo. Rabbit eyes were given new SCL containing 150ug of PFD and 0.5% PFD eye drops served as control, and PFD concentration were detected by high performance liquid chromatography (HPLC) in tears at different time points following the PFD loaded contact lens placed on the cornea of rabbits.
Slit-lamp microscopic examination showed the novel designed SCL suits rabbits’ eyes well. Compared with eye drops, the drug-loaded contact lens increased the concentration of PFD in tears. PFD can be detected in tears up to 10 hours after following the PFD loaded contact lens placed on the cornea of rabbits. After wearing the SCL for consecutive 24h, no obvious irritation on rabbit eyes was observed and Draize scored 0.
The novel drug delivery contact lens showed significant improvement of the bioavailability of PFD while having no obvious toxicity and irritation on the rabbit eyes. A soft contact lens is an ideal delivery system for long-lasting effective retention of PFD, suggesting SCL would be an ideal carrier of PFD to realize the long-lasting effective retention on eyes.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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