July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Surface Imaging of ParasolTM and QuintessTM Punctal Plugs following extrusion
Author Affiliations & Notes
  • Abid Haseeb
    Ophthalmology, University of Illinois at Chicago, Rockford, Illinois, United States
  • Daniel J. Oh
    Ophthalmology, University of Illinois at Chicago, Rockford, Illinois, United States
  • Olivia Thomson
    Research Resources Center, University of Illinois at Chicago, Illinois, United States
  • Smajo Osmanovic
    Ophthalmology, University of Illinois at Chicago, Rockford, Illinois, United States
  • DEEPAK P EDWARD
    Ophthalmology, University of Illinois at Chicago, Rockford, Illinois, United States
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
  • Footnotes
    Commercial Relationships   Abid Haseeb, None; Daniel Oh, None; Olivia Thomson, None; Smajo Osmanovic, None; DEEPAK EDWARD, None
  • Footnotes
    Support  1. Edwin F Schild Foundation, 2. NEI (P30 EY001792, Core Grant for Vision Research), 3. RPB departmental grant (Unrestricted Grant from Research to Prevent Blindness)
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4300. doi:https://doi.org/
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    • Get Citation

      Abid Haseeb, Daniel J. Oh, Olivia Thomson, Smajo Osmanovic, DEEPAK P EDWARD; Surface Imaging of ParasolTM and QuintessTM Punctal Plugs following extrusion. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4300. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The type and architecture of punctal plugs are believed to affect the rates of punctal extrusion. We used scanning electron microscopy (SEM) and histopathology to study the surface of extruded implants in two brands of punctal plugs (ParasolTM and QuintessTM).

Methods : Extruded punctal plugs from 8 human subjects (5 ParasolTM plugs, 3 QuintessTM plugs) and an unused control plug from each brand were studied with Hitachi S-3000 Variable Pressure SEM and light microscopy in some specimens. Structural irregularity (dents, scratches, and manufacturing defects) and tissue accumulation were graded (none, mild, moderate, severe) at the collarette, neck, and head regions of each plug. Percentage change for structural irregularities across collarette, neck, and head regions were calculated between extruded and control samples. These were compared for both ParasolTM and QuintessTM plugs.

Results : In both ParasolTM and QuintessTM control plugs, structural irregularities were mild or absent in the collarette and neck regions. However, the ParasolTM control head region had severe structural irregularity. In the extruded ParasolTM plugs, the head region had increased tissue accumulation (4/5 severe ParasolTM versus 1/3 in QuintessTM). Sites of tissue accumulation are summarized in Table 1. Histopathology of plugs that showed tissue enveloping the neck demonstrated intact and/or disrupted non-keratinized stratified squamous canalicular epithelium overlying fibrovascular stroma suggestive of a pyogenic granuloma (Figure 1). The percentage increase of surface irregularity when comparing extruded and control ParasolTM plugs was calculated as 100% in the neck and 30% in the head. The percentage increase of surface irregularity when comparing extruded and control QuintessTM plugs was calculated as 100% in the collarette, 67% in the neck, and 30% in the head.

Conclusions : Parasol plugs appear to have inherent structural irregularities more concentrated in the head region which may predispose to tissue accumulation in that area. Given the putative role of pyogenic granuloma formation in punctal plug extrusion, it is important to consider such architectural alterations in the plug that may contribute to punctal plug extrusion.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Scoring of sites of accumulation on ParasolTM and QuintessTM punctal plugs

Scoring of sites of accumulation on ParasolTM and QuintessTM punctal plugs

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