July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Evaluation of Risuteganib as a neuroprotective agent in retinal dystrophy, using the Rabin cone contrast test
Author Affiliations & Notes
  • Vanessa Tirado
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Luis A. Hernández
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Santiago Soberón
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Elsa C. Hernández
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Jazmin Baca Moreno
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Enrique Garcia
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Luis Daniel Garcia Arzate
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Yurico Lopez
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Ana Gonzalez-H.Leon
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Ana Suárez Licona
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Virgilio Morales-Canton
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Hugo Quiroz-Mercado
    Retina, Asociacion para evitar la ceguera en Mexico, Mexico City, Coyoacan, Mexico
  • Footnotes
    Commercial Relationships   Vanessa Tirado, None; Luis Hernández, None; Santiago Soberón, None; Elsa Hernández, None; Jazmin Baca Moreno, None; Enrique Garcia, None; Luis Daniel Garcia Arzate, None; Yurico Lopez, None; Ana Gonzalez-H.Leon, None; Ana Suárez Licona, None; Virgilio Morales-Canton, None; Hugo Quiroz-Mercado, Allegro Ophtalmics (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 45. doi:
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    • Get Citation

      Vanessa Tirado, Luis A. Hernández, Santiago Soberón, Elsa C. Hernández, Jazmin Baca Moreno, Enrique Garcia, Luis Daniel Garcia Arzate, Yurico Lopez, Ana Gonzalez-H.Leon, Ana Suárez Licona, Virgilio Morales-Canton, Hugo Quiroz-Mercado; Evaluation of Risuteganib as a neuroprotective agent in retinal dystrophy, using the Rabin cone contrast test. Invest. Ophthalmol. Vis. Sci. 2019;60(9):45.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Risuteganib has been shown, in cell-line and animal models, to demonstrate neuroprotective properties. In this study, we evaluate safety and potential efficacy of intravitreal Risuteganib in patients with retinal dystrophy.

Methods : Prospective, interventional study of 3 patients (6 eyes) with retinal dystrophies (cone-rod distrophy) where Rabin cone contrast test (RCCT) and acuity test (Innova Systems, Burr Ridge, IL) was taken prior and after a single administration of 1.0mg of intravitreal Risuteganib in the left eye. The right eye was used as a control. Patients were recruited in the genetics department of the hospital based on ophthalmic history and complete ophthalmic evaluation.

Results : The three patients with retinal dystrophy had a mean age of 20.03 ± 4.04 (range 18-25) years old. The complete ophthalmologic examination showed no signs of toxicity in any of the patients.

The RCCT showed improvement after administration of intravitreal Risuteganib in all 3 patients. Left eye values (prior to Risuteganib administration) [L CCTs (5.0 ± 5.0), M CCTs (15.0 ± 15.0), S CCTs (80.0 ± 15.0)]. Left eye values (one month after administration of Risuteganib) [L CCTs (8.3 ± 14.43), M CCTs (23.3 ± 20.81, S CCTs (78.3 ± 25.65)]. The mean change from baseline were L CCT 3.3, M CCT 8.3, S CCT -1.7.

Right eye values (no Risuteganib was administrated) [L CCTs (11.6 ± 20.2), M CCTs (16.6 ± 14.43), S CCTs (76.6 ± 11.54)]. Right eye values (one month follow-up examination) [L CCTs (13.3 ± 15.27), M CCTs (16.6 ± 28.86), S CCTs (78.3 ± 18.92)]. The mean change from baseline were L CCT 1.7, M CCT 0.0, S CCT 1.7.


The difference in CFB between study and control group is the following: L CCT 1.6, M CCT 8.3, S CCT -1.7.

Conclusions : In this study we demonstrate that intravitreal Risuteganib improves color vision, suggesting neuroprotective properties, and could be a promising treatment for retinal dystrophy. Intravitreal Risuteganib did not show adverse effects on any of these patients.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

 

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