July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Influence of significant astigmatism error in the quantitative analysis of OCT-A images.
Author Affiliations & Notes
  • Rosa Dolz-Marco
    Department of Ophthalmology, OFTALVIST CLINIC, Valencia, Spain
  • Cristina Vinacua
    Optics, Optometrhy and Visual Science, Faculty of Physics. University of Valencia, Valencia, Spain
  • Victor Esteve
    Department of Ophthalmology, OFTALVIST CLINIC, Valencia, Spain
  • Miguel Palomares
    Department of Ophthalmology, OFTALVIST CLINIC, Valencia, Spain
  • Carlos Zapata-Rodriguez
    Optics, Optometrhy and Visual Science, Faculty of Physics. University of Valencia, Valencia, Spain
  • Roberto Gallego-Pinazo
    Department of Ophthalmology, OFTALVIST CLINIC, Valencia, Spain
  • Footnotes
    Commercial Relationships   Rosa Dolz-Marco, Heidelberg Engineering (C), Novartis (F), Roche/Genentech (F); Cristina Vinacua, None; Victor Esteve, None; Miguel Palomares, None; Carlos Zapata-Rodriguez, None; Roberto Gallego-Pinazo, Heidelberg Engineering (F), Novartis (C), Roche (F), Thrombogenics (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4531. doi:
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      Rosa Dolz-Marco, Cristina Vinacua, Victor Esteve, Miguel Palomares, Carlos Zapata-Rodriguez, Roberto Gallego-Pinazo; Influence of significant astigmatism error in the quantitative analysis of OCT-A images.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4531.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the influence of astigmatism errors in the qualitative and quantitative analysis of optical coherence tomography angiography (OCT-A) images.

Methods : Patients undergoing a comprehensive ophthalmic evaluation including OCT-A scans were included in the study. The OCT-A images were acquired using Spectralis HRA-OCT2 (Heidelberg Engineering, Heidelberg, Germany). In the same visit, 10°x10° High-Resolution OCT-A images were acquired with and without astigmatism correction using the follow-up tool. Qualitative analysis (no changes, subtle changes, substantial changes) was performed by 2 independent graders (RDM, RGP). Quantitative analysis included skeletonized vessel density (sVD) of the superficial, intermediate and deep capillary plexus (SCP, ICP, DCP respectively) and the choriocapillaris (CC). Statistical analysis was performed using SPSS.

Results : Five hundred eyes of 264 patients were included in the present study. Median astigmatism error was -0.75 diopters [range: 0.25-5.50]. Qualitative analysis was significantly influenced by astigmatism error greater than 2.50 diopters (p<0.05). In the uncorrected scans, artefactual increase of vessel diameter of the greater retinal vessels was observed within the SCP, associated with a decrease in the visualization of the small capillaries in the SCP, ICP, and DCP. Values of sVD of the SCP, ICP, DCP and CC were significantly influenced by astigmatism errors (p<0.001).

Conclusions : OCT-A images provide valuable depth-resolved information on the vascular layers of the retina and choroid. However, different factors influence the quantitative analysis of OCT-A images, limiting our ability to extract conclusive data from this relatively novel modality. Our results suggest that correction of significant astigmatism errors may be required in studies including quantitative OCT-A analysis.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

En face OCT-A reconstruction of the left eye of a 41-year-old healthy male with – 3.25 astigmatism error. Images of the SCP, ICP and DCP were taken without astigmatism correction (top row) and after astigmatism correction (bottom row). Differences in the thickness of the greater retinal vessels are shown in the SCP. The visualization and delineation of the small capillaries within the SCP, ICP and DCP is also limited in the top row images compared to the bottom row images.

En face OCT-A reconstruction of the left eye of a 41-year-old healthy male with – 3.25 astigmatism error. Images of the SCP, ICP and DCP were taken without astigmatism correction (top row) and after astigmatism correction (bottom row). Differences in the thickness of the greater retinal vessels are shown in the SCP. The visualization and delineation of the small capillaries within the SCP, ICP and DCP is also limited in the top row images compared to the bottom row images.

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