Abstract
Purpose :
The alterations brain function of short range functional connectivity density (IFCD) and long range functional connectivity density (longFCD) in monocular blind (MB) patients have not been studied by any researches. Resting-state functional connectivity (rsFC) analysis is an effective means to measure the spontaneous functional organization. The purpose of this paper is to determine the FCD differences between the MB patients and normal controls (NCs) via rsFC method.
Methods :
Totally 32 MB patients (18 males and 14 females), and the same number of NCs (18 males and 14 females) with matched sex, age and education conditions received a functional MRI scans at the resting state. The IFCD and longFCD were compared by one sample t test. The MB patients were distinguishable from the NCs by receiver operating characteristic (ROC) curves.
Results :
Compared with NCs, significant increased IFCD value were found in both Superior Frontal Gyrus, left Inferior Frontal Gyrus, right Inferior Parietal Lobule (IPL), increased longFCD value were found in left SFG. Significant reduced IFCD value were found in left Cerebellum Posterior Lobe (CPL), bilateral Thalamus, right Lingual Gyrus, and right Anterior Cingulate. Significant reduced longFCD value were found in right Middle Occipital Gyrus, right Cingulate Gyrus, and bilateral Cuneus.
Conclusions :
MB indicated increased binarized IFCD and long IFCD in chronic pain sensoring related brain areas, which might give an explanation of brain function compensation for the chronic eye pain disorders in MB patients. Reduced binarized IFCD and long IFCD in CPL, IPL may provide an explanation of vision loss.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.