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Kira Wang, Xi Chen, Sandra Stinnett, Vincent Tai, Du Tran-Viet, Cynthia Toth; Understanding the variability of handheld spectral-domain optical coherence tomography measurements in supine infants. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB046.
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Central foveal thickness (CFT) measurements are critically important in the assessment of foveal development and retinal diseases in infants and children. The repeatability and reproducibility of CFT measurements in non-sedated infants is not known. The aim of this retrospective study is to evaluate the variation and reproducibility of supine handheld SDOCT (hh-SDOCT) imaging in infants compared to conventional tabletop imaging of fixating adults.
Two groups were selected for this retrospective study. Group 1 included 25 imaging sessions from 21 preterm infants (mean age at imaging 39 weeks) without macular edema imaged supine in the nursery using hh-SDOCT (Bioptigen, RTP, NC). Group 2 included 25 imaging sessions from 25 adults without eye disease, imaged using tabletop SDOCT (Farsiu et. al, Ophthalmology 2014). For each imaging session, three macular, zero-degree volume scans from one eye were selected. CFTs (distance between the internal limiting membrane and the Bruch’s membrane) for all 150 scans were measured using a customized script for automatic segmentation with manual correction. The coefficient of variations (CV) were calculated over all 25 imaging sessions for both handheld and tabletop systems. The intraclass correlation coefficients (ICC) were calculated with a 95% confidence interval to assess the reproducibility of both systems.
The mean CFT was 157.1 ± 35.6 μm for Group 1 and 244.5 ± 18.4 μm for Group 2. CFT measurements from hh-SDOCT imaging of supine infants and tabletop imaging of fixating adults were reproducible. The mean CV was 3.8 for Group 1 (infants) and 2.1 for Group 2 (adults). The ICC (95% confidence interval) was 0.94 (0.90, 0.97) for Group 1 and 0.91 (0.83, 0.96) for Group 2.
CFT measurements using both handheld and tabletop SDOCT systems were reproducible. In the developing infant eye, these reproducible measures can be useful in the application to neonatal studies in the nursery.
This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.
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