August 2019
Volume 60, Issue 11
Open Access
ARVO Imaging in the Eye Conference Abstract  |   August 2019
Variables Affecting Ocular Vessel Density Measurements
Author Affiliations & Notes
  • Maria de los Angeles Ramos Cadena
    NYU Langone Eye Center, NYU Langone Health, New York, New York, United States
  • Gadi Wollstein
    NYU Langone Eye Center, NYU Langone Health, New York, New York, United States
  • Joel S Schuman
    NYU Langone Eye Center, NYU Langone Health, New York, New York, United States
  • Katie Lucy
    NYU Langone Eye Center, NYU Langone Health, New York, New York, United States
  • Mengfei Wu
    NYU Langone Eye Center, NYU Langone Health, New York, New York, United States
    Division of Biostatistics, Departments of Population Health and Environmental Medicine, NYU Langone Health, New York, New York, United States
  • Mengling Liu
    NYU Langone Eye Center, NYU Langone Health, New York, New York, United States
    Division of Biostatistics, Departments of Population Health and Environmental Medicine, NYU Langone Health, New York, New York, United States
  • Ravneet Singh Rai
    NYU Langone Eye Center, NYU Langone Health, New York, New York, United States
  • Jesus Jiménez-Román
    Glaucoma, Asociación Para Evitar la Ceguera en México, Mexico City, Mexico, Mexico
  • Gabriel Lazcano-Gómez
    Glaucoma, Asociación Para Evitar la Ceguera en México, Mexico City, Mexico, Mexico
  • Mariana Hernández-Monroy
    Glaucoma, Asociación Para Evitar la Ceguera en México, Mexico City, Mexico, Mexico
  • Joong Wong Shin
    College of Medicine, University of Ulsan, Asan Medical Center, Department of Ophthalmology, Seoul, Seoul, Korea (the Republic of)
    University of Ulsan, Gangneung Asan Hospital,, Gangneung, Korea., Korea (the Republic of)
  • Sung Kyung Rim
    College of Medicine, University of Ulsan, Asan Medical Center, Department of Ophthalmology, Seoul, Seoul, Korea (the Republic of)
  • Hiroshi Ishikawa
    NYU Langone Eye Center, NYU Langone Health, New York, New York, United States
  • Footnotes
    Commercial Relationships   Maria de los Angeles Ramos Cadena, None; Gadi Wollstein, None; Joel Schuman, Zeiss (P); Katie Lucy, None; Mengfei Wu, None; Mengling Liu, None; Ravneet Rai, None; Jesus Jiménez-Román, None; Gabriel Lazcano-Gómez, None; Mariana Hernández-Monroy, None; Joong Wong Shin, None; Sung Kyung Rim, None; Hiroshi Ishikawa, None
  • Footnotes
    Support  R01-EY013178
Investigative Ophthalmology & Visual Science August 2019, Vol.60, PB056. doi:https://doi.org/
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    • Get Citation

      Maria de los Angeles Ramos Cadena, Gadi Wollstein, Joel S Schuman, Katie Lucy, Mengfei Wu, Mengling Liu, Ravneet Singh Rai, Jesus Jiménez-Román, Gabriel Lazcano-Gómez, Mariana Hernández-Monroy, Joong Wong Shin, Sung Kyung Rim, Hiroshi Ishikawa; Variables Affecting Ocular Vessel Density Measurements. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB056. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the effect of co-variables commonly used in ocular structure models on ocular vessel density (VD) measurements provided by OCT angiography (OCTA)

Methods : Healthy subjects with a normal comprehensive ophthalmic examination, axial length (AL) measurements, qualified visual fields (VF; Humphrey Field Analyzer; Zeiss, Dublin, CA), and optic nerve head (ONH) and macula OCT and OCTA scans (Cirrus HD-OCT 200x200 cube scans and 3x3 mm/ 6x6 mm Angioplex; Zeiss) were included. Subjects with comorbidities affecting the systemic or local micro or macro vasculature and subjects taking medications that modify vessel diameter were excluded. Peripapillary, ONH, and macular VD were calculated using the device's native software. Mixed-effects models were used accounting for age, gender, signal strength, AL, and inter- and intra-subject correlation.

Results : 72 eyes (46 subjects) with a mean age of 45.1 (±13.9) years, mean AL of 23.82 (±1.03) mm, and mean signal strength of 8.32 (±1.04) were included in the study for ONH analysis and a subset of 33 eyes were included for macular analysis. The 3x3 and 6x6 ONH inner VD measurements decrease as age advances (-0.1 ±0.02 mm/mm2, p=0.005; -0.07 ±0.02 mm/mm2, p=0.0026, respectively). The central and inner measurements in the 3x3 macular scans decrease with age (-0.14 ±0.03 mm/mm2, p=0.0006; -0.06 ±0.01mm/mm2, p=0.0003, respectively). ONH and macula VD in both scanning sizes were not associated with AL, except for the macula 6x6 outer region (0.41 ±0.05 mm/mm2, p=0.05). Only macular VD measurements were associated with signal strength.

Conclusions : When analyzing ocular VD, the variables of age, AL, and image quality, should be considered.

This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.

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