August 2019
Volume 60, Issue 11
Open Access
ARVO Imaging in the Eye Conference Abstract  |   August 2019
Structure function correlation in uveitic cystoid macular edema and treatment response using non-invasive Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Sophia Zagora
    Moorfields Eye Hospital, United Kingdom
    Ophthalmology, Save Sight Institute, Sydney Eye Hospital and University of Sydney, Sydney, New South Wales, Australia
  • Dilraj Grewal
    Moorfields Eye Hospital, United Kingdom
    Duke Eye Center, North Carolina, United States
  • Oren Tomkins-Netzer
    Ophthalmology, UCL, London, United Kingdom
    Ophthalmology, Bnai Zion Medical Center, Technion – Israel Institute of Technology, Haifa, Israel
  • Sue Lightman
    Ophthalmology, UCL, London, United Kingdom
  • Footnotes
    Commercial Relationships   Sophia Zagora, None; Dilraj Grewal, None; Oren Tomkins-Netzer, None; Sue Lightman, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science August 2019, Vol.60, PB073. doi:https://doi.org/
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      Sophia Zagora, Dilraj Grewal, Oren Tomkins-Netzer, Sue Lightman; Structure function correlation in uveitic cystoid macular edema and treatment response using non-invasive Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB073. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We conducted a cross sectional cohort study to investigate whether the structural integrity of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and the size of the largest intraretinal cyst and the preserved retinal tissue on en face imaging using optical coherence tomography angiography (OCTA) correlates with vision and is predictive of visual recovery after treatment in eyes with uveitic cystoid macular edema (CME).

Methods : Patients with non-infectious uveitic CME (>320 microns) who underwent local steroid treatment had baseline and follow up en face OCTA images (Zeiss Angioplex, Carl Zeiss Meditec) with a scanning area of 3×3-mm centered on the fovea. The SCP in the ganglion cell layer and the DCP beneath the inner plexiform layer (IPL) were measured. The FAZ area (3×3mm) of each vascular layer was calculated after conversion to 8-bit grayscale images using ImageJ software (NIH, Bethesda, MD). The border of the FAZ was manually drawn by two retinal specialists. The preserved retinal tissue on baseline en face OCT imaging, FAZ area in the SCP and DCP and disorganization of retinal inner layers (DRIL) in the central 1000 microns were correlated with best-corrected logMAR VA.

Results : Thirty-five eyes of 30 patients (14 female, 16 male) with a mean age of 52 and vision of 38 letters were included. Mean vascular density in the SCP was 13.50±4.67% and DCP was 10.57±2.64%. Mean FAZ in the SCP was 0.28±0.12mm2 and DCP was 1.09±0.47. Correlation coefficients for baseline VA (ETDRS letters) correlated with the vessel density in the SCP (0.64, p=0.08) and DCP (r=0.78, p=0.019). There was also a negative correlation with the area of the FAZ in the SCP (r=-0.33, p=0.24) and DCP (r=-0.40, p=0.19) with vision. DRIL in the central 1000
microns correlated negatively with vision. (r=-0.37, p=0.21). Area of largest cyst at baseline on en face OCT correlated with vision (r=-0.66, p=0.1).

Conclusions : Using OCTA, vessel density in the SCP and DCP, correlated with VA. Similarly there was a negative correlation of FAZ area in the SCP and DCP with vision. Structural integrity of the layers and preserved retinal tissue on en face OCTA negatively correlated with vision indicating that the vascular and structural changes in the DCP and SCP on OCTA could serve as a non invasive surrogate biomarker for VA.

This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.

 

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