August 2019
Volume 60, Issue 11
Free
ARVO Imaging in the Eye Conference Abstract  |   August 2019
Temporal Retinal Nerve Fiber Bundle Changes in Glaucoma Imaged with OCT-Reflectance - Correlation with Circumpapillary OCT Retinal Nerve Fiber Layer Thickness.
Author Affiliations & Notes
  • Maria V. Castanos Toral
    Research, New York Eye and Ear Infirmmary, Mount Sinai, New York City, New York, United States
  • Davis B Zhou
    Research, New York Eye and Ear Infirmmary, Mount Sinai, New York City, New York, United States
    Icahn School of Medicine, New York City, New York, United States
  • Erica B. Jacobs
    Research, New York Eye and Ear Infirmmary, Mount Sinai, New York City, New York, United States
  • Jorge S Andrade Romo
    Research, New York Eye and Ear Infirmmary, Mount Sinai, New York City, New York, United States
  • Donald C. Hood
    Department of Psychology, Columbia University, New York City, New York, United States
    Department of Ophthalmology, Columbia University, New York City, New York, United States
  • Robert Ritch
    Research, New York Eye and Ear Infirmmary, Mount Sinai, New York City, New York, United States
  • Richard B Rosen
    Research, New York Eye and Ear Infirmmary, Mount Sinai, New York City, New York, United States
    Icahn School of Medicine, New York City, New York, United States
  • Toco YP Chui
    Research, New York Eye and Ear Infirmmary, Mount Sinai, New York City, New York, United States
    Icahn School of Medicine, New York City, New York, United States
  • Footnotes
    Commercial Relationships   Maria Castanos Toral, None; Davis Zhou, None; Erica Jacobs, None; Jorge Andrade Romo, None; Donald Hood, None; Robert Ritch, Aeon Astron (C), Axim (C), Diopsys (C), Glauconix (C), Guardion (I), Intelon (C), Mitotech (C); Richard Rosen, Astellas (C), Bayer (C), Boehringer-Ingelheim (C), Diopsys (C), Genentech-Roche (C), Guardion (I), NanoRetina (C), OD-OS (C), Opticology (I), Optovue (C), Regeneron (C), Teva (C); Toco Chui, None
  • Footnotes
    Support  R01EY027301
Investigative Ophthalmology & Visual Science August 2019, Vol.60, PB0118. doi:
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    • Get Citation

      Maria V. Castanos Toral, Davis B Zhou, Erica B. Jacobs, Jorge S Andrade Romo, Donald C. Hood, Robert Ritch, Richard B Rosen, Toco YP Chui; Temporal Retinal Nerve Fiber Bundle Changes in Glaucoma Imaged with OCT-Reflectance - Correlation with Circumpapillary OCT Retinal Nerve Fiber Layer Thickness.. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB0118.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the correlation between retinal nerve fiber bundle (RNFB) width along the temporal raphe and circumpapillary retinal nerve fiber layer (cpRNFL) thickness in glaucomatous eyes using OCT-reflectance (OCT-R) and OCT, respectively.

Methods : 7 controls and 11 primary open angle glaucoma (POAG) patients with either superior or inferior arcuate visual field defects were imaged using a SDOCT system (Avanti RTVue-XR; Optovue). Ten 3x3mm scans centered at 9° temporal to the fovea were obtained and averaged (Mo PMID:28068370). A OCT-R slab located between the ILM and 15µm below was used for RNFB width measurement (Fig A1 & B1). On the OCT-R, six 80-100 µm RNFB segments located above and below the temporal raphe were identified. RNFB width was then measured based on the first derivative of the straightened RNFB intensity profiles. Corresponding cpRNFL thickness in the superior and inferior quadrants was measured in each participant (Heidleberg Spectralis HRA + OCT) (Fig A2 & B2). Relationship between RNFB width and cpRNFL thickness were evaluated using linear regression.

Results : RNFBs along the temporal raphe were clearly visualized in all controls and POAG patients using OCT-reflectance (Fig A1 & B1). RNFB width along the temporal raphe was decreased in all POAG patients (control: 34.07±7.96µm vs POAG: 23.77±4.32µm). cpRNFL thickness thinning was found in the POAG patients (control: 125.8±15.85µm vs POAG: 69.61±19.98µm). Statistical significant correlation was found between the RNFB width and cpRNFL thickness (linear regression; r=0.56, P=0.0008).

Conclusions : Glaucomatous damage on temporal RNFB width measured using OCT-reflectance is associated with cpRNFL thickness thinning measured using the OCT. For glaucomatous RNFB damage detection, RNFB imaging along the temporal raphe using OCT-reflectance may provide additional information to the cpRNFL thickness.

This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.

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