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Yu Kawashima, Akihito Uji, Manabu Miyata, Satoshi Morooka, Yuki Muraoka, Tadamichi Akagi, Akitaka Tsujikawa; Choriocapillaris imaging in patients with Behcet′s disease using optical coherence tomography angiography and image averaging. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB0125.
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© ARVO (1962-2015); The Authors (2016-present)
Imaging of the choriocapillaris (CC) in diseased eyes requires advanced imaging technology such as optical coherence tomography angiography (OCTA). In our recent study, the image averaging technique showed the CC in detail. The averaging technique made possible to compare normal eye and disease eye using on OCTA. This study was undertaken to investigate the CC in patients with Behcet′s disease (BD) using en-face image averaging on OCTA.
This was a retrospective case study. OCTA imaging of the macula, covering a 3×3 mm area centered on the fovea, was performed using the commercially available HS100 HR-SD-OCT system (Canon Inc., Tokyo, Japan). Each eye underwent 10 OCTA scans, which were averaged to obtain high image quality cube data via the built-in software. The CC slab was binarized, and the number and size of flow voids were quantified. Retinal projection artifacts were removed before CC quantification. External limiting membrane (ELM), ellipsoid zone (EZ), and cone outer segment termination (COST) status were separately judged by 2 retinal specialists.
Forty-four eyes (26 eyes of patients with BD; 18 normal eyes) were included. ELM, EZ, and COST damage were more frequently observed in patients with BD than in those with normal eyes (27% vs 0%, P = 0.046; 27% vs 0%, P = 0.047; and 77% vs 0%, P <.0001, respectively). Flow void counts were significantly smaller in patients with BD than in those with normal eyes (1275 ± 275 vs 1488 ± 216; P = 0.001). Total area of flow voids were significantly larger in patients with BD than in those with normal eyes (61066 ± 15670 vs 49409 ± 15040; P = 0.040). Average size of flow voids were larger in patients with BD than in those with normal eyes (53 ± 28 vs 35 ± 15; P = 0.010). The percentage area of flow voids were higher in patients with BD than in those with normal eyes (28 ± 7 vs 23 ± 7; P = 0.040). In BD patients with eye symptoms versus those with no eye symptoms, counts, total area, average size, and percentage area of flow void were not significantly different (P = 0.857, 0.562, 0.833, and 0.562, respectively).
Averaged images of CC in patients with BD showed significant damage and larger and sparser flow voids than those of normal eyes. Our results indicated that patients with BD had CC damage in the absence of ocular attacks, which could be detected using OCTA.
This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.
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