August 2019
Volume 60, Issue 11
Open Access
ARVO Imaging in the Eye Conference Abstract  |   August 2019
Choriocapillaris imaging in patients with Behcet′s disease using optical coherence tomography angiography and image averaging
Author Affiliations & Notes
  • Yu Kawashima
    Kyoto university, Kyoto, Japan
  • Akihito Uji
    Kyoto university, Kyoto, Japan
  • Manabu Miyata
    Kyoto university, Kyoto, Japan
  • Satoshi Morooka
    Kyoto university, Kyoto, Japan
  • Yuki Muraoka
    Kyoto university, Kyoto, Japan
  • Tadamichi Akagi
    Kyoto university, Kyoto, Japan
  • Akitaka Tsujikawa
    Kyoto university, Kyoto, Japan
  • Footnotes
    Commercial Relationships   Yu Kawashima, None; Akihito Uji, Alcon pharma (R), Canon (R), Santen (R), Senju (R); Manabu Miyata, Alcom pharma (R), Alcon Japan (F), Santen (R); Satoshi Morooka, Alcon pharma (R), Eisai (R), Santen (F), Tanabe Mitubishi (R); Yuki Muraoka, Bayer Pharmaceuticals (R), Nidek (R), Novartis Pharma (R), Santen (R), Senju (R); Tadamichi Akagi, Alcon Japan (R), Bayer pharma (R), Canon (R), Kowa (R), Otsuka Pharmaceutical (R), Pfizer (R), Santen (R), Senju (R); Akitaka Tsujikawa, Alcon Japan (F), Alcon Japan (R), Alcon pharma (F), AMO japan (F), Atuzawa proteze (F), Bayer (F), Bayer pharmaceuticals (R), Bayer Pharmaceuticals (F), Canon (F), HOYA (F), JFC Sales Plan (F), JMIA (F), Kowa (F), Novartis pharma (R), Novartis Pharma (F), Pfizer (R), Santen (F), Senju (F), Tomey corporation (F), Wakamoto (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science August 2019, Vol.60, PB0125. doi:https://doi.org/
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      Yu Kawashima, Akihito Uji, Manabu Miyata, Satoshi Morooka, Yuki Muraoka, Tadamichi Akagi, Akitaka Tsujikawa; Choriocapillaris imaging in patients with Behcet′s disease using optical coherence tomography angiography and image averaging. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB0125. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Imaging of the choriocapillaris (CC) in diseased eyes requires advanced imaging technology such as optical coherence tomography angiography (OCTA). In our recent study, the image averaging technique showed the CC in detail. The averaging technique made possible to compare normal eye and disease eye using on OCTA. This study was undertaken to investigate the CC in patients with Behcet′s disease (BD) using en-face image averaging on OCTA.

Methods : This was a retrospective case study. OCTA imaging of the macula, covering a 3×3 mm area centered on the fovea, was performed using the commercially available HS100 HR-SD-OCT system (Canon Inc., Tokyo, Japan). Each eye underwent 10 OCTA scans, which were averaged to obtain high image quality cube data via the built-in software. The CC slab was binarized, and the number and size of flow voids were quantified. Retinal projection artifacts were removed before CC quantification. External limiting membrane (ELM), ellipsoid zone (EZ), and cone outer segment termination (COST) status were separately judged by 2 retinal specialists.

Results : Forty-four eyes (26 eyes of patients with BD; 18 normal eyes) were included. ELM, EZ, and COST damage were more frequently observed in patients with BD than in those with normal eyes (27% vs 0%, P = 0.046; 27% vs 0%, P = 0.047; and 77% vs 0%, P <.0001, respectively). Flow void counts were significantly smaller in patients with BD than in those with normal eyes (1275 ± 275 vs 1488 ± 216; P = 0.001). Total area of flow voids were significantly larger in patients with BD than in those with normal eyes (61066 ± 15670 vs 49409 ± 15040; P = 0.040). Average size of flow voids were larger in patients with BD than in those with normal eyes (53 ± 28 vs 35 ± 15; P = 0.010). The percentage area of flow voids were higher in patients with BD than in those with normal eyes (28 ± 7 vs 23 ± 7; P = 0.040). In BD patients with eye symptoms versus those with no eye symptoms, counts, total area, average size, and percentage area of flow void were not significantly different (P = 0.857, 0.562, 0.833, and 0.562, respectively).

Conclusions : Averaged images of CC in patients with BD showed significant damage and larger and sparser flow voids than those of normal eyes. Our results indicated that patients with BD had CC damage in the absence of ocular attacks, which could be detected using OCTA.

This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.

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