August 2019
Volume 60, Issue 11
Open Access
ARVO Imaging in the Eye Conference Abstract  |   August 2019
Chemical cross-linking: a new choice for the bullous keratopathy treatment
Author Affiliations & Notes
  • Mengmeng Wang
    Hebei Provincial Eye Hospital, Xingtai, Hebei, China
  • Minglian Zhang
    Hebei Provincial Eye Hospital, Xingtai, Hebei, China
  • Footnotes
    Commercial Relationships   Mengmeng Wang, None; Minglian Zhang, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science August 2019, Vol.60, PB0139. doi:https://doi.org/
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      Mengmeng Wang, Minglian Zhang; Chemical cross-linking: a new choice for the bullous keratopathy treatment. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB0139. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the effects of corneal CXL using chemical agents (glyceraldehyde and genipin) on the rabbit bullous keratopathy models established by descemetorhexis.

Methods : 35 rabbits were randomly divided into five groups. Group A (n = 5) is the control group. The right eyes of animals in Groups B, C, D, E, F, and G (n = 5, resp.) were suffered with descemetorhexis procedures. From the 8th day to the 14th day postoperatively, the right eyes in Groups C, D and F were instilled with hyperosmolar drops, glyceraldehydedrops, and genipin drops respectively; the right eyes in Group E and G were instilled with hyperosmolar-glyceraldehyde drops and hyperosmolar-genipin dropsrespectively. Centralcorneal thickness (CCT), corneal transparency score, and histopathological analysis were applied on the eyes in each group.

Results : Compared with Group A, statistically significant increase in CCT and corneal transparency score was found in Groups B, C, D, E, F and G at 7 d postoperatively (P < 0.05) and in Groups C, D, E, F and G at 14d postoperatively (P < 0.05).

Conclusions : Chemical CXL improved the CCT and corneal transparency of the rabbit bullous keratopathy models. Topical instillation with hyperosmolar-glyceraldehyde/genipin solution seems to be a good choice for the bullous keratopathy treatment.

This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.

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