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Mengmeng Wang, Minglian Zhang; Chemical cross-linking: a new choice for the bullous keratopathy treatment. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB0139.
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To evaluate the effects of corneal CXL using chemical agents (glyceraldehyde and genipin) on the rabbit bullous keratopathy models established by descemetorhexis.
35 rabbits were randomly divided into five groups. Group A (n = 5) is the control group. The right eyes of animals in Groups B, C, D, E, F, and G (n = 5, resp.) were suffered with descemetorhexis procedures. From the 8th day to the 14th day postoperatively, the right eyes in Groups C, D and F were instilled with hyperosmolar drops, glyceraldehydedrops, and genipin drops respectively; the right eyes in Group E and G were instilled with hyperosmolar-glyceraldehyde drops and hyperosmolar-genipin dropsrespectively. Centralcorneal thickness (CCT), corneal transparency score, and histopathological analysis were applied on the eyes in each group.
Compared with Group A, statistically significant increase in CCT and corneal transparency score was found in Groups B, C, D, E, F and G at 7 d postoperatively (P < 0.05) and in Groups C, D, E, F and G at 14d postoperatively (P < 0.05).
Chemical CXL improved the CCT and corneal transparency of the rabbit bullous keratopathy models. Topical instillation with hyperosmolar-glyceraldehyde/genipin solution seems to be a good choice for the bullous keratopathy treatment.
This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.
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