August 2019
Volume 60, Issue 11
Open Access
ARVO Imaging in the Eye Conference Abstract  |   August 2019
Photoacoustic signal-guided photo-mediated ultrasound therapy as a novel method to remove microvasculature
Author Affiliations & Notes
  • Yixin Yu
    University of Michigan, Ann Arbor, Michigan, United States
    Xiangya Hospital, Central South University, Changsha, Hunan, China
  • Wei Zhang
    University of Michigan, Ann Arbor, Michigan, United States
  • Yu Qin
    University of Michigan, Ann Arbor, Michigan, United States
  • Xinyi Xie
    University of Michigan, Ann Arbor, Michigan, United States
  • Xinmai Yang
    University of Kansas, Kansas, United States
  • Xueding Wang
    University of Michigan, Ann Arbor, Michigan, United States
  • Yannis M Paulus
    University of Michigan, Ann Arbor, Michigan, United States
  • Footnotes
    Commercial Relationships   Yixin Yu, None; Wei Zhang, None; Yu Qin, None; Xinyi Xie, None; Xinmai Yang, None; Xueding Wang, None; Yannis Paulus, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science August 2019, Vol.60, PB0172. doi:
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      Yixin Yu, Wei Zhang, Yu Qin, Xinyi Xie, Xinmai Yang, Xueding Wang, Yannis M Paulus; Photoacoustic signal-guided photo-mediated ultrasound therapy as a novel method to remove microvasculature. Invest. Ophthalmol. Vis. Sci. 2019;60(11):PB0172.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Real-time image-guided retinal laser therapy allows for automatic feedback to reliably and reproducibly treat the vasculature. We have developed a novel, controllable, signal-guided photo-mediated ultrasound therapy (PUT). PUT can selectively treat blood vessels using a combination of low intensity nanosecond pulse duration laser and ultrasound without damaging surrounding tissue under real-time guidance of photoacoustic (PA) signal.

Methods : An integrated PA sensing and PUT system was developed to investigate the feasibility of using a laser system (Continuum Powerlite DLS 8010, Santa Clara, CA) and ultrasound transducer (H107, Sonic Concepts, Bothell, WA) for PA sensing and PUT treatment in real-time. Nd: YAG laser was used as the source to produce laser and the ultrasound transducer was used to deliver ultrasound bursts to the treatment area and detect PA signals in real-time. During PUT treatment, different anti-vascular effects were induced in an in vivo chicken yolk sac membrane model, 45 samples were involved. The anti-vascular effects related PA signal changes were immediately detected with PA sensing.

Results : PA signals were acquired before and immediately after PUT. Statistically significant differences were found before and after treatment in shrinkage and rupture effect. A significant decrease in PA signal amplitude was observed with vessel shrinkage, whereas vessel rupture induced a significant increase in PA signal. The real-time detected PA signals were divided into three groups based on the treatment effect. When no treatment was noted on the target vessels, no notable change was shown in detected PA signal. PA signal decreased significantly with PUT vessel shrinkage. PA signal amplitude increased abruptly with PUT causing vessel rupture until the bleeding stabilized.

Conclusions : With the capability to precisely control the treatment effects, PA-guided PUT holds significant promise as a novel, non-invasive, controllable method to treat the eye microvasculature with reduced side-effects and no systemic photosensitizing dye.

This abstract was presented at the 2019 ARVO Imaging in the Eye Conference, held in Vancouver, Canada, April 26-27, 2019.

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