June 2020
Volume 61, Issue 7
ARVO Annual Meeting Abstract  |   June 2020
Large Scale, Prospective, Multicenter, Clinical Evaluation of Point-of-Care Lymphotoxin alpha (LTA) Test in Dry Eye Disease
Author Affiliations & Notes
  • Xiang Lin
    Xiamen University, Xiamen, China
  • Jing-Feng Huang
    Seinda Biomedical Corp, China
  • Zuguo Liu
    Xiamen University, Xiamen, China
  • Footnotes
    Commercial Relationships   Xiang Lin, None; Jing-Feng Huang, None; Zuguo Liu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 116. doi:
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      Xiang Lin, Jing-Feng Huang, Zuguo Liu; Large Scale, Prospective, Multicenter, Clinical Evaluation of Point-of-Care Lymphotoxin alpha (LTA) Test in Dry Eye Disease. Invest. Ophthalmol. Vis. Sci. 2020;61(7):116.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To evaluate the diagnostic value of a point-of-care (POC) Lymph toxin alpha (LTA-POC) test in dry eye disease (DED).

Methods : Participants were assessed using the Ocular Surface Disease Index(OSDI) ocular symptom sub-scale. Tear fluid were collected and LTA-POC test was performed to measure LTA, before conducting the following tests: tear break-up time (TBUT), and corneal fluorescein staining (CFS), and Schirmer’s test. The receiver operating characteristic (ROC) curve was used to evaluate LTA as a biomarker for dry eye diagnosis.

Results : The study enrolled 1088 subjects: 782 patients with clinical signs and symptoms of dry eye and 306 non-dry eye controls. LTA level in dry eye group (0.64±1.35, ng/mL) was significantly lower than control group (2.05±2.92, ng/mL) (P<0.001). LTA level correlated positively with Schirmer test and TBUT, and correlated negatively with OSDI score, CFS and conjunctival hyperemia (all of them P<0.001) . Kappa value was 0.496 (95%CI: 0.438~0.553)(P<0.001). With ROC curve analysis, area under the curve (AUC) was 0.765 (95% CI: 0.731~0.800).

Conclusions : Findings from this large prospective clinical study support LTA as a biomarker for dry eye digsnosis. They also support the intended use of LTA-POC tear test as a point of care immunoassay to be used in facilitating diagnosis of dry eye.

This is a 2020 ARVO Annual Meeting abstract.


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