June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Association of coffee, tea, and caffeine consumption with intraocular pressure and interaction with genetic risk: findings from the UK Biobank
Author Affiliations & Notes
  • Jihye Kim
    Epidemiology , Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States
  • Hugues Aschard
    Department of Computational Biology, Institute Pasteur, Paris, France
  • Jae H. Kang
    Channing Division of Network Medicine, Brigham and Women’s Hospital/Harvard Medical School, Boston, Massachusetts, United States
  • Marleen AH Lentjes
    School of Medical Sciences, Örebro University, Orebro, Sweden
  • Janey Wiggs
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
  • Anthony Khawaja
    NIHR Biomedical Research Centre at Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom
  • Louis R Pasquale
    Department of Ophthalmology, Icahn School of Medicine, New York, New York, United States
  • Footnotes
    Commercial Relationships   Jihye Kim, None; Hugues Aschard, None; Jae Kang, None; Marleen Lentjes, None; Janey Wiggs, None; Anthony Khawaja, None; Louis Pasquale, Bausch+Lomb (C), Emerald Bioscience (C), Eyenovia (C), Nicox (C), Verily (C)
  • Footnotes
    Support  R01 EY 0150473
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 52. doi:
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    • Get Citation

      Jihye Kim, Hugues Aschard, Jae H. Kang, Marleen AH Lentjes, Janey Wiggs, Anthony Khawaja, Louis R Pasquale; Association of coffee, tea, and caffeine consumption with intraocular pressure and interaction with genetic risk: findings from the UK Biobank. Invest. Ophthalmol. Vis. Sci. 2020;61(7):52.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Coffee and tea are commonly consumed caffeinated beverages that may affect ocular health. Hence, it is of interest whether caffeine intake affects intraocular pressure (IOP). Some studies reported that coffee and caffeine consumption is associated with higher IOP. However, evidence from large-scale general population studies is limited.

Methods : We included 121,755 UK Biobank participants (aged 39-73y) who had dietary data and cornea-compensated IOP measurements in 2006-2010. In a subset (n=78,017), data were available from up to five web-based 24-hour-recall food frequency questionnaires (2009-2012); we derived participants’ total caffeine consumption based on caffeine content and frequency of caffeine-containing food intake. Using multivariable linear regression, we assessed the cross-sectional relationships between coffee or tea intake (cups/day) and IOP (mmHg) as primary analyses and the associations between total caffeine intake (80 mg/day) and IOP (mmHg) as secondary analyses. Analyses were adjusted for age, sex, ethnicity, smoking, alcohol intake, physical activity, deprivation, body mass index, blood pressure, and diabetes (and total energy intake in the subset). To explore gene-diet interactions, we examined interactions between coffee, tea, caffeine intake and an IOP polygenic risk score (PRS) combining effects of 111 genetic variants associated with IOP identified by genome-wide association studies.

Results : Mean (SD) IOP was 16.0 (3.8) mmHg. Higher coffee, tea, and total caffeine intakes were associated with lower IOP (-0.049, -0.045 and -0.039 mmHg, respectively; P ≤ 0.001). When evaluating PRS-diet interactions, we found positive and significant interactions with tea and caffeine intake (both P-interactions < 0.05), where higher tea and caffeine intake was associated with lower IOP among individuals with IOP PRS in the lower 75th percentile, while among individuals with high IOP PRS (top 25th percentile), higher intakes were associated with modestly higher IOP.

Conclusions : We found evidence for very weak associations between higher coffee, tea and caffeine intake and lower IOP. However, our finding on gene-diet interactions suggest that genetic predisposition to higher IOP may influence the association between caffeinated beverage consumption and IOP.

This is a 2020 ARVO Annual Meeting abstract.

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