Purchase this article with an account.
Marrie van der Mooren, Steven Safran, Henk A Weeber, Patricia Piers; Trend in Glistening density in Acrylic Intraocular Lenses and its relation to straylight performance. Invest. Ophthalmol. Vis. Sci. 2020;61(7):599.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
The purpose of this study was to evaluate trends in glistening density in acrylic intraocular lenses (IOLs) and its relation to straylight performance
Ten recently produced lenses of three acrylic IOL materials A, B and C were used for testing. All IOLs were immersed in a 0.9% saline solution. Glistening density and stray light performance were measured before and after one temperature cycle from room temperature to 35 degrees C for 15 hours and back to room temperature. Glistening density was determined using Image J to analyze darkfield microscopy images. The Miyata grading scale was used to classify the glistening density as mild, moderate and severe. Glistening density data were compared to historic data for the same IOL materials. The stray light performance was evaluated in white light for a 4mm pupil and visual angles up to 22 degrees. The straylight levels were compared to a reference level of a 20-year-old healthy crystalline lens. The maximum straylight parameter was correlated with glistening density by means of regression analysis.
The in-vitro applied temperature cycle appears representative for in- vivo material performance. For material A there is variability in glistening density ranging from 25 to 257 microvacuoles/mm2. There were two IOLs in the severe glistening grade, five in the moderate group and three in the mild group. For material B and C all glistenings were in the mild group. The glistening density findings for all IOL materials continue to be of the same order of magnitude as historically reported for the last 7 years. For material A there is a variability in straylight levels. After the temperature cycle, seven out of ten IOLs had significant elevated straylight values. These correlated with all IOLs in the moderate or severe glistening group. Glistening density and straylight performance are highly correlated (R2=0.95) using the maximum straylight parameter.
Glistening density and straylight performance are highly correlated. The majority of ten recent manufactured and tested IOLs from material A continue to show significant level of glistenings and elevated straylight levels.
This is a 2020 ARVO Annual Meeting abstract.
This PDF is available to Subscribers Only