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Xiao Shang, Xiaoyan Wang, Kun Zhou, Yuanbo Liang; Faster Macular Vessel Density Loss in Moderate to Severe Primary Open Angle Glaucoma Eyes. Invest. Ophthalmol. Vis. Sci. 2020;61(7):622.
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To evaluate and compare the rates of macular vessel density (VD) loss in the superficial layer among primary open angle glaucoma eyes across different disease stages.
This is a longitudinal, observational study. A total of 103 eyes (53 eyes in mild stage, 34 eyes in moderate stage and 16 eyes in severe stage) of 75 primary open angle glaucoma (POAG) patients followed for more than 1 year with at least 2 qualified optical coherence tomography angiography (OCT-A) imaging were included. Glaucoma disease stage was identified by mean deviation (MD)of standard automated perimetry results. The rates of macular VD loss in the superficial layer were determined by linear regression and compared using the generalized linear mixed models among 3 groups. Mixed effect models were used to evaluate the demographic and ocular parameters associated with the macular superficial VD loss rate.
In the mean followed-up of 2.36 years, the rates of macular superficial VD loss were significantly different from zero in all sectors. The rates of macular VD loss were significantly faster in moderate stage and severe stage groups than in mild stage group in whole en-face (-2.35%/yr vs -1.47%/yr,p=0.005, -2.70%/yr vs -1.47%/yr, p=0.015), superior hemifield (-2.19%/yr vs -1.22%/yr, p=0.006, -2.55%/yr vs -1.22%/yr p=0.015), inferior hemifield (-2.26%/yr vs -1.70%/yr, p=0.034, -2.38%/yr vs -1.70%/yr, p=0.072), parafoveal (-2.25%/yr vs -1.41, p=0.004, -2.15%/yr vs -1.41, p=0.011), superior (-1.66%/yr vs -1.13%/yr, p=0.010, -2.42%/yr vs -1.13%/yr, p=0.009), nasal quadrant sectors (-1.81%/yr vs -0.95%/yr p=0.003, -2.87%/yr vs -0.95%/yr, p=0.025). Baseline MD, vertical cup to disc ratio, rim area, ganglion cell-inner plexiform layer thickness, retinal nerve fyber layer thickness were associated with the rates of macular whole en-face VD loss.
OCT-A measurements could detect The rates of macular VD loss were significantly faster in POAG eyes with moderate and severe stage glaucomatous visual field damage than with mild stage damage. Disease stage is associated with structural progression of glaucoma in terms of macular VD loss.
This is a 2020 ARVO Annual Meeting abstract.
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