Investigative Ophthalmology & Visual Science Cover Image for Volume 61, Issue 7
June 2020
Volume 61, Issue 7
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ARVO Annual Meeting Abstract  |   June 2020
Translaminar pressure differences and ocular hemodynamic parameters between normal and high-tension glaucoma, ocular hypertension and healthy subjects
Brent A Siesky; Lina Siaudvytyte; Ingrida Januleviciene; Akvile Stoskuviene; Ragauskas Arminas; Alice Chandra Verticchio Vercellin; Nicholas Kalafatis; Alon Harris
Author Affiliations & Notes
  • Brent A Siesky
    Ophthalmology, Icahn School of Medicine at Mount Sinai, Zionsville, Indiana, United States
  • Lina Siaudvytyte
    Eye Clinic of Kaunas Medical Academy of Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Ingrida Januleviciene
    Eye Clinic of Kaunas Medical Academy of Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Akvile Stoskuviene
    Eye Clinic of Kaunas Medical Academy of Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Ragauskas Arminas
    Health Telematics Science Centre of Kaunas University of Technology, Kaunas, Lithuania
  • Alice Chandra Verticchio Vercellin
    Ophthalmology, Icahn School of Medicine at Mount Sinai, Zionsville, Indiana, United States
    University of Pavia, Italy
  • Nicholas Kalafatis
    Indiana University School of Medicine, Indiana, United States
  • Alon Harris
    Ophthalmology, Icahn School of Medicine at Mount Sinai, Zionsville, Indiana, United States
  • Footnotes
    Commercial Relationships   Brent Siesky, None; Lina Siaudvytyte, None; Ingrida Januleviciene, Novartis (C), Origmed (C), Santen (R), Santen (C), Thea (C), Vittamed (C); Akvile Stoskuviene, None; Ragauskas Arminas, None; Alice Chandra Verticchio Vercellin, None; Nicholas Kalafatis, None; Alon Harris, AdOM (C), AdOM (I), AdOM (S), AdOM (R), LuSeed (I), Oxymap (I), Thea (R)
  • Footnotes
    Support  R01EY030851: Integration of clinical measures and theoretical modeling to quantify sectorial specific changes in ocular structure, function, and hemodynamics
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 626. doi:
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      Brent A Siesky, Lina Siaudvytyte, Ingrida Januleviciene, Akvile Stoskuviene, Ragauskas Arminas, Alice Chandra Verticchio Vercellin, Nicholas Kalafatis, Alon Harris; Translaminar pressure differences and ocular hemodynamic parameters between normal and high-tension glaucoma, ocular hypertension and healthy subjects. Invest. Ophthalmol. Vis. Sci. 2020;61(7):626.

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Abstract

Purpose : To assess differences in translaminar pressure difference (TPD), and ocular hemodynamic parameters between normal-tension (NTG) and high-tension (HTG) glaucoma, ocular hypertension (OH) and healthy subjects (HS).

Methods : 100 NTG (57.5(10.9)yr), 100 HTG (57.5(10.9)yr), 40 OH (47.0(9.6)yr) and 100 HS (57.4(10.6)yr) were assessed for: intraocular pressure (IOP), non-invasive intracranial pressure (ICP, via Vittamed UAB, Lithuania), resistance indexes (RI) in the ophthalmic (OA), central retinal (CRA), temporal short posterior (tSPA) arteries (color Doppler imaging, Accuvix, Korea), blood pressure (BP) and body mass index (BMI). TPD was calculated as: TPD=IOP–ICP. Results of p<0.05 were considered statistically significant.

Results : HS had statistically significantly lower TPD, compared to NTG, HTG, and OH (3.6(2.1), 6.3(2.6), 17.7(5.4) and 13.5(3.4) mmHg, respectively, p<0.05). NTG was associated with TPD>4.68mmHg (odds ratio, OR:6.018; 95%confident interval, CI:3.263-11.097), OA RI>0.705 (OR:3.667; 95%CI:2.012-6.682), CRA RI>0.605 (OR:4.056; 95%CI:2.235-7.359), tSPCA RI>0.475 (OR:3.622; 95%CI:1.995-6.567), p<0.05 (discriminating HS and NTG). Comparing HTG and HS, TPD value>8.83mmHg was found in 99% HTG and 0% in HS, p<0.001. HTG was associated with CRA RI>0.605 (OR:3.174; 95%CI:1.757-5.733), tSPCA RI>0.485 (OR:3.995; 95%CI:2.211-7.215), diastolic BP>83.0mmHg (OR:2.613; 95%CI:1.466-4.658), BMI>28.8kg/m2 (OR:2.267; 95%CI:1.218-4.217), p<0.05(discriminating HS and HTG). Comparing NTG and HTG it was found that OA RI>0.705 was associated with NTG (OR:1.839; 95%CI:1.002-5.372), p<0.05. Comparing OH and HS TPD value>8.65mmHg was found in 97.5% OH and 0% HS, p<0.001. OH was associated with OA RI>0.685 (OR:4.827; 95%CI:1.862-12.517), tSPCA RI>0.485 (OR:3.030; 95%CI:1.410-6.511), p<0.05 (discriminating healthy subjects and OH). Comparing HTG and OH it was found that TPD>15.34mmHg was associated with HTG (OR:5.824; 95% CI:2.548-13.311), p=0.01.

Conclusions : Lower TPD was associated with higher risk of NTG, while higher TPD was associated with OH and HTG. Higher OA RI was associated with NTG. Further studies are analyzing TPD in glaucoma management are warranted.

This is a 2020 ARVO Annual Meeting abstract.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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