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Karin R Pillunat, Maike Anja Haase, Lutz E Pillunat, Robert Herber; Changes in corneal backscatter 6 months after trabeculectomy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):962.
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© ARVO (1962-2015); The Authors (2016-present)
To study possible changes in corneal backscatter, 6 months after mitomycin C (MMC) augmented trabeculectomy and to compare these measurements with healthy controls. Further, to investigate possible correlations with potential causing factors.
Corneal backscatter was monitored with the Pentacam HR3 (Oculus, Wetzlar, Germany) densitometry module before and 6 months after first-time uncomplicated MMC augmented trabeculectomy in 42 eyes of 42 Caucasian open-angle glaucoma patients and in 38 healthy controls of the same age group. The difference in IOP pre- and postoperatively, known duration of the disease, central corneal thickness, gender, the number of substances, applications and amount of benzalkonium chloride per day as well as postoperative topical corticoid use were tested for possible correlations. Statistical analysis was performed using linear mixed models to compare pre- and postoperative values. A P-value lower than 0.05 was considered as statistically significant.
Densitometry measurements were statistically significantly reduced in the entire cornea from 25.5±5.7 to 23.1±5.8 grayscale units (GSU; P=0.001) 6 months after trabeculectomy with emphasis in the anterior layer. They returned close to normal and were not statistically significantly different compared to a healthy control group (21.9±2.8 GSU; P=0.213) of the same age group. No correlations could be found with these observations and possible causing factors.
Corneal densitometry, an objective and sensitive measure of corneal transparency, returned close to normal 6 months after trabeculectomy. Although the observations cannot be associated with any causing factors in this study, the complete cessation of topical antiglaucomatous medications including benzalkonium chloride seems to be the most plausible reason for this finding.
This is a 2020 ARVO Annual Meeting abstract.
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