June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Functional evaluation of the visual field sensitivity in chronic central serous chorioretinopathy with and without choroidal vascular hyperpermeability
Author Affiliations & Notes
  • Rion Ozawa
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Keiko Azuma
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Ryo Terao
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Youhei Hashimoto
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Kunihiro Azuma
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Kohei Ueda
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Tatsuya Inoue
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Ryo Obata
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Rion Ozawa, None; Keiko Azuma, None; Ryo Terao, None; Youhei Hashimoto, None; Kunihiro Azuma, None; Kohei Ueda, None; Tatsuya Inoue, None; Ryo Obata, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1074. doi:
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      Rion Ozawa, Keiko Azuma, Ryo Terao, Youhei Hashimoto, Kunihiro Azuma, Kohei Ueda, Tatsuya Inoue, Ryo Obata; Functional evaluation of the visual field sensitivity in chronic central serous chorioretinopathy with and without choroidal vascular hyperpermeability. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1074.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Chronic central serous chorioretinopathy (cCSC) is associated with an increase in choroidal thickness, known to the term “pachychoroid,” as well as choroidal vessel dilation and choroidal vascular hyperpermeability (CVH). However, the detail function of CVH has not been documented to date. The aim of this study was to evaluate the functional evaluation of the visual field sensitivity between with and without CVH in cCSC.

Methods : Fourteen eyes presenting with resolved CSC were examined with fluorescein and indocyanine green angiography (FA/IA), fundus autofluorescence (FAF), optical coherence tomography angiography (OCTA), and visual field (VF) test corresponding to the HFA 10-2 program containing 68 test points. CVH regions were identified by IA imaging and the IA images were superimposed with the result from the visual field test. The difference between the average retinal sensitivity (RS) inside and outside of the CVH area was compared.
The relationship between RS, visual acuity, retinal structure, and the presence of choroidal neovascularization (CNV) were analyzed using univariate and multivariate analysis.

Results : Among the 14 eyes with cCSC, CNV was identified by OCTA in 7 (50%) cases. However, FA/IA imaging failed to identify any presence of CNV in all cases. Two cases (14%) showed RPE atrophy on FAF. Mean best corrected visual acuity (BCVA), central retinal thickness (CRT), central choroidal thickness (CCT), and choroidal luminal area were 0.01±0.12 logMAR, 162±34μm, 353±119μm, 64±3.7%, respectively.
The difference between the average RS inside and outside of the CVH region was 0.18±0.9dB. The presence of CNV on OCTA within the CVH region was the only factor significantly associating with higher difference in RS between inside and outside of the CVH region (P< 0.046).

Conclusions : OCTA provides a promising CNV detection rate in cCSC compared with FAIA. CVH with CNV on OCTA may contribute to a decrease in RS.

This is a 2020 ARVO Annual Meeting abstract.

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