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Eileen E Birch, Yolanda S Castaneda, Christina S Cheng-Patel, Sarah E Morale, Krista R Kelly, Reed M Jost, Lindsey A Hudgins, David A Leske, Jonathan M Holmes; Eye-Related Quality of Life (ER-QOL), Vision, Visuomotor Function, and Self-Perception in Children with Strabismus, Anisometropia, or Both. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1143.
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© ARVO (1962-2015); The Authors (2016-present)
In order to formally evaluate the construct validity of the patient-derived Child Pediatric Eye Questionnaire (Child PedEyeQ), we evaluated associations between ER-QOL and functional measures (vision, visuomotor function, self-perception) in children with strabismus, anisometropia, or both. Our hypothesis was that children with functional deficits would have lower ER-QOL as quantified by their Child PedEyeQ domain scores.
We evaluated 114 children (aged 5 to 11 years) with strabismus (n=32; 10 amblyopic), anisometropia (n=40; 19 amblyopic), or both (n=42; 26 amblyopic) who had ≤0.2 logMAR better eye visual acuity (ATS-HOTV or E-ETDRS). Each child completed the Child PedEyeQ to assess 4 Rasch-scored domains of ER-QOL: Functional Vision, Bothered by Eyes/Vision, Social, and Frustration/Worry. In addition, children completed one or more of the following tests: Randot Preschool Stereoacuity (RPST; n=92), Contrast Balance Index (CBI, depth of suppression; n=87), Readalyzer reading (n=44), vergence instability (n=50), MABC-2 manual dexterity (n=57), Pictorial Scale of Perceived Competence and Social Acceptance for Young Children (self-perception of cognitive competence, physical competence, peer acceptance, and maternal acceptance; n=44).
Child PedEyeQ Functional Vision domain scores were correlated with CBI (r=-0.29, p=0.003), reading speed (r=0.50, p=.0005), manual dexterity (r=0.26, p=.05), and self-perception of physical competence (r=0.63, p<.0001) and peer acceptance (r=0.39, p=.009). Child PedEyeQ Bothered by Eyes/Vision, Social, and Frustration/Worry domain scores all were correlated with worse eye VA (r=-0.21 to -0.27, p=.02 to .002), CBI (r=-0.29 to -0.30, p=.003 to .002), vergence instability (r=-0.33 to -0.41, p=0.02 to 0.003), and self-perception of physical competence (r=0.45 to 0.56, p=.002 to <.0001) and peer acceptance (r=0.37 to 0.52, p=.007 to .0003).
Children with impaired vision, impaired visuomotor function, and/or worse self-perception have lower ER-QOL domain scores, supporting the construct validity of the Child PedEyeQ and its use as an outcome measure in interventional clinical trials for strabismus, anisometropia, and amblyopia.
This is a 2020 ARVO Annual Meeting abstract.
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