Abstract
Purpose :
To determine the range of normal MPOD values in healthyIndian eyes by dual-wavelength autofluorescence to establish a normative database.
Methods :
Sixty eyes of 31 healthy subjects (12 males; 19 females) of south Indian population were enrolled between September 2019 and October 2019 in this Institutional Review Board approved study. Written informed consent was obtained from the subjects per the Declaration of Helsinki. We included subjects with best corrected visual acuity of 20/20 or better, intraocular pressure ≥10 mmHg and ≤21 mmHg, and without any ocular or systemic pathology, family history or age-related macular degeneration, history of smoking, or carotenoids and/or vitamin or antioxidant supplementation.
MPOD was measured with a dual-wavelength (486 and 518 nm) autofluorescence method with the Spectralis after pupillary dilation. The device assumed absence of macular pigment at 6° foveal eccentricity as a reference to generate MP density maps. The average MPOD at 1° and 2° radii and sum of MPOD volume at 1°, 2°, and 6° radii were recorded. All analyses were performed using SPSS version 21.0. P values less than 0.05 were considered statistically significant.
Results :
The mean age was 39.1 ± 12.7 years (range: 21-65 years). The mean MPOD value and volume were 0.38 ± 0.11 and 787.95 ± 225.13 at 1° eccentricity; 0.23 ± 0.08 and 2000 ± 708.24 at 2° eccentricity; 0.05 ± 0.02 and 4335 ± 2007.71 at 6° eccentricity. Minimum and maximum MPOD were 0.11 and 0.67 at 1° eccentricity; 0.04 and 0.41 at 2° eccentricity; 0.00 and 0.11 at 6° eccentricity, respectively. In the ETDRS grid, maximum MPOD was noted in zone 1 (the central subfield) and minimum MPOD was noted in zone 9 (outer inferior perifovea).
Conclusions :
This study established the MPOD normogram in healthy eyes in Indian population. This normative database can be used when analyzing the MPOD values in diseased eyes in future studies.
This is a 2020 ARVO Annual Meeting abstract.