June 2020
Volume 61, Issue 7
ARVO Annual Meeting Abstract  |   June 2020
Quality of life survey using NEI VFQ-25 in patients with aniridia
Author Affiliations & Notes
  • Chie Inokuchi
    Department of Ophthalmology, Osaka University, Japan
  • Yoshinori Oie
    Department of Ophthalmology, Osaka University, Japan
  • Nozomi Nishida
    Department of Ophthalmology, Osaka University, Japan
  • Tomomi Yamada
    Osaka University, Japan
  • Jun Shimazaki
    Department of Ophthalmology, Tokyo Dental College, Japan
  • Shigeto Shimmura
    Department of Ophthalmology, Keio University, Japan
  • Chie Sotozono
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
  • Atsushi Shiraishi
    Department of Ophthalmology, Ehime University, Japan
  • Tomohiko Usui
    Department of Ophthalmology, International University of Health and Welfare Graduate School, Japan
  • Akira Murakami
    Department of Ophthalmology, Juntendo University, Japan
  • Kazunori Miyata
    Miyata Eye Hospital, Japan
  • Kohji Nishida
    Department of Ophthalmology, Osaka University, Japan
  • Footnotes
    Commercial Relationships   Chie Inokuchi, None; Yoshinori Oie, None; Nozomi Nishida, None; Tomomi Yamada, None; Jun Shimazaki, None; Shigeto Shimmura, None; Chie Sotozono, None; Atsushi Shiraishi, None; Tomohiko Usui, None; Akira Murakami, None; Kazunori Miyata, None; Kohji Nishida, None
  • Footnotes
    Support  Reseach on rare and intractable diseases,Health,Labour and Welfare Sciences Research Grants(Grants Number:H29-Nanchitou(Nan)-Ippan-011,Principal Investigator:Koji Nishida)
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1576. doi:
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      Chie Inokuchi, Yoshinori Oie, Nozomi Nishida, Tomomi Yamada, Jun Shimazaki, Shigeto Shimmura, Chie Sotozono, Atsushi Shiraishi, Tomohiko Usui, Akira Murakami, Kazunori Miyata, Kohji Nishida; Quality of life survey using NEI VFQ-25 in patients with aniridia. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1576.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To survey quality of life in patients with aniridia using NEI VFQ-25

Methods : Seventy-three eyes of 37 patients who were diagnosed as definite or probable aniridia by the research group to establish the standard diagnosis and treatment for corneal intractable diseases were included in the study. The average age was 47.4 ± 14.4 years. Sixteen males and 21 females were included. The average corrected distance visual acuity (CDVA) was 1.35 ± 0.70 logMAR. We conducted an interview survey using the Japanese version of NEI VFQ-25, and investigated the correlation between CDVA of the dominant eye and the total score or subscales using Spearman's rank correlation coefficient.

Results : The average total score (component 11) was 56.2 ± 13.8. The average of the subscales were 45.8 ± 17.7 for general vision, 66.6 ± 18.4 for ocular pain, 52.2 ± 19.1 for near vision, 47.2 ± 18.3 for distance vision, 67.9 ± 22.8 for social function, 41.1 ± 18.4 for mental health, 54.7 ± 18.5 for role limitation, 60.8 ± 22.5 for dependency, 0 for driving, 83.6 ± 13.5 for color vision, and 46.6 ± 22.2 for peripheral vision. CDVA in the dominant eye had significant negative correlations with eye pain, distance vision, and social function. (Each R = -0.326, p = 0.049, R = -0.339, p = 0.040, R = -0.364, p = 0.027)

Conclusions : Quality of life was low in patients with aniridia. Lower corrected distance visual acuity of the dominant eye was associated with worse eye pain, distance vision, and social function.

This is a 2020 ARVO Annual Meeting abstract.


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