June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Characterization of Diabetic Macular Edema in a Colony of Cynomolgus Monkeys
Author Affiliations & Notes
  • Chi-Wai Wong
    HZ-Biosciences, Guangzhou, China
  • Fan Shuxin
    Zhongshan Ophthalmic Center, China
  • Wei Liu
    HZ-Biosciences, Guangzhou, China
  • Liangzhi Xu
    HZ-Biosciences, Guangzhou, China
  • Jian Luo
    NGM Biopharmaceuticals, California, United States
  • Xialin Liu
    Zhongshan Ophthalmic Center, China
  • youjin hu
    Zhongshan Ophthalmic Center, China
  • Footnotes
    Commercial Relationships   Chi-Wai Wong, HZ-Biosciences (E); Fan Shuxin, None; Wei Liu, HZ-Biosciences (E); Liangzhi Xu, HZ-Biosciences (E); Jian Luo, NGM Biopharmaceuticals (E); Xialin Liu, None; youjin hu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1768. doi:
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      Chi-Wai Wong, Fan Shuxin, Wei Liu, Liangzhi Xu, Jian Luo, Xialin Liu, youjin hu; Characterization of Diabetic Macular Edema in a Colony of Cynomolgus Monkeys. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1768.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Diabetic maculopathy is the most common cause of vision impairment in individuals with diabetic retinopathy. Optical coherence tomography (OCT) is one of the fundamental diagnostic imaging techniques in retinal assessment, especially diabetic macular edema (DME). By using OCT, we aimed to identify animals with DME by assessing the macular thickness in a colony of diabetic cynomolgus monkeys. These animals were further characterized with an anti-VEGF therapy.

Methods : Twenty-six age matched euglycemic and thirty-eight diabetic cynomolgus monkeys with fasting plasma glucose > 7mM and HbA1C > 6% were examined by OCT (Spectralis OCT-Plus, Heidelberg, Germany). Retinal thickness was measured at the fovea (F) and 1.5mm to the nasal (N) and temporal (T) side. Nine diabetic monkeys with retinal thickening were then treated once by intravitreal injection of an anti-VEGF therapy. The retinal thickness of these 9 diabetic animals were monitored every 4 weeks for 16 weeks.

Results : The retinal thickness of 26 euglycemic monkeys were 324 -/+ 15 mm (N), 204 -/+ 8 mm (F), and 309 -/+ 13 mm (T). Using exceeding 2 standard deviations of normal retinal thickness as a criteria, we identified 11 diabetic animals with a certain degree of DME. The most affected area is the fovea. Intravitreal injection of an anti-VEGF therapy significantly improved the DME in these animals as measured by OCT.

Conclusions : Non-human primates with DME were identified. The DME is characterized by swelling mostly at the fovea and has many similarities to the changes observed in human. Intravitreal injection of anti-VEGF therapy improved the DME in these animals.

This is a 2020 ARVO Annual Meeting abstract.

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