Quantification of retinal microvasculature in DR using wide-filed SS-OCTA

Abstract

Purpose : To analysis microvascular parameters of each stage of diabetic retinopathy with different range of views using wide-field swept-source OCTA

Methods : 106 diabetic patients (153 eyes), either without retinopathy or with different degrees of retinopathy, were retrospectively recruited for volumetric swept-source OCTA imaging using 12mm x 12mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to quantify areas of capillary nonperfusion in 3mm x 3 mm, 6mm x 6 mm, and 12mm x 12mm fields with adjusted angle

Results : The mean percentage of nonperfused area calculated in the 6mm x 6 mm, and 12mm x 12mm fields were 0.06mm², 2.40 mm² in the eyes without DR; 0.20 mm², 2.77 mm² in the mild nonproliferative DR eyes, 0.39 mm², 7.50 mm² in the moderate nonproliferative DR eyes, 1.00 mm², 14.47 mm² in the severe nonproliferative DR eyes, and 2.05 mm², 24.75 mm² in the proliferative DR eyes. The percentage of nonperfused area significantly increased with severity DR in 6mm x 6 mm, and 12mm x 12mm fields, but not in 3mm x 3 mm field.

Conclusions : Capillary nonperfusion area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion on wide-field OCTA may be useful for early detection and monitoring of disease in patients with diabetes and DR

This is a 2020 ARVO Annual Meeting abstract.