June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Segmentation errors in optical coherence tomography scans of age-related macular degeneration patients with polypoidal choroidal vasculopathy
Author Affiliations & Notes
  • Ki Woong Bae
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Baek-Lok Oh
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Hyeong Gon Yu
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Ki Woong Bae, None; Baek-Lok Oh, None; Hyeong Gon Yu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1810. doi:
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    • Get Citation

      Ki Woong Bae, Baek-Lok Oh, Hyeong Gon Yu; Segmentation errors in optical coherence tomography scans of age-related macular degeneration patients with polypoidal choroidal vasculopathy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1810.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the factors associated with optical coherence tomography (OCT) segmentation errors (SEs) in neovascular age-related macular degeneration (nAMD) patients with polypoidal choroidal vasculopathy (PCV)

Methods : Medical records of patients with nAMD from multi-center collaborative studies performed at South Korea were reviewed. OCT scans were taken by Cirrus OCT using the 512 x 128 scan pattern and analyzed with version 10.0.0. software.

Results : OCT images from 60 eyes of 60 (41 male, 19 female) nAMD patients with PCV were evaluated. The average signal strength of OCT scan was 6.3 ± 2.3 (2 - 10). The mean Central subfield thickness (CFT) was 347.3 ± 92.3 (193 - 574 ). SEs were observed in 17 (28.3 %) of the patients with 11 (64.7 %) patients having significant errors in central 1-mm subfield which means change of retinal thickness more than 10% after manual correction. SEs were divided into two groups: misidentification of foveal center (11 eyes) called the off center artifact and errors in retinal boundary detection (6 eyes). Off center artifacts have a significant association with central subfield thickness (CFT) measurement errors, but not with retinal surface misidentification errors (p = 0.03 vs 0.068). Various macular pathologic findings including pigment epithelium detachments, subretinal fluids, and intraretinal cysts have shown no clinical significance with SEs or CFT measurement errors.

Conclusions : OCT SEs occurred frequently in nAMD patients with PCV and often resulted in CFT measurement errors, which had a significant association with errors caused by misidentification of fovea.

This is a 2020 ARVO Annual Meeting abstract.

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