Abstract
Purpose :
To examine the factors associated with optical coherence tomography (OCT) segmentation errors (SEs) in neovascular age-related macular degeneration (nAMD) patients with polypoidal choroidal vasculopathy (PCV)
Methods :
Medical records of patients with nAMD from multi-center collaborative studies performed at South Korea were reviewed. OCT scans were taken by Cirrus OCT using the 512 x 128 scan pattern and analyzed with version 10.0.0. software.
Results :
OCT images from 60 eyes of 60 (41 male, 19 female) nAMD patients with PCV were evaluated. The average signal strength of OCT scan was 6.3 ± 2.3 (2 - 10). The mean Central subfield thickness (CFT) was 347.3 ± 92.3 (193 - 574 ). SEs were observed in 17 (28.3 %) of the patients with 11 (64.7 %) patients having significant errors in central 1-mm subfield which means change of retinal thickness more than 10% after manual correction. SEs were divided into two groups: misidentification of foveal center (11 eyes) called the off center artifact and errors in retinal boundary detection (6 eyes). Off center artifacts have a significant association with central subfield thickness (CFT) measurement errors, but not with retinal surface misidentification errors (p = 0.03 vs 0.068). Various macular pathologic findings including pigment epithelium detachments, subretinal fluids, and intraretinal cysts have shown no clinical significance with SEs or CFT measurement errors.
Conclusions :
OCT SEs occurred frequently in nAMD patients with PCV and often resulted in CFT measurement errors, which had a significant association with errors caused by misidentification of fovea.
This is a 2020 ARVO Annual Meeting abstract.