June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Longitudinal changes in ellipsoid zone relative reflectivity in eyes with and without reticular pseudodrusen in intermediate age-related macular degeneration
Author Affiliations & Notes
  • Sarah Thiele
    Centre for Eye Research Australia, Victoria, Australia
    Department of Ophthalmology, University of Bonn, Germany
  • Ben Isselmann
    Department of Ophthalmology, University of Bonn, Germany
  • Zhichao Wu
    Centre for Eye Research Australia, Victoria, Australia
  • Emily Caruso
    Centre for Eye Research Australia, Victoria, Australia
  • Lauren A.B. Hodgson
    Centre for Eye Research Australia, Victoria, Australia
  • Pyrawy Sivarajah
    Centre for Eye Research Australia, Victoria, Australia
  • Elizabeth Kate Baglin
    Centre for Eye Research Australia, Victoria, Australia
  • Robyn H Guymer
    Centre for Eye Research Australia, Victoria, Australia
    Ophthalmology, Department of Surgery, The University of Melbourne, Victoria, Australia
  • Chi D Luu
    Centre for Eye Research Australia, Victoria, Australia
    Ophthalmology, Department of Surgery, The University of Melbourne, Victoria, Australia
  • Footnotes
    Commercial Relationships   Sarah Thiele, Bayer (R), Carl Zeiss Meditec (F), CenterVue (F), Heidelberg Engineering (F), Heidelberg Engineering (R), Novartis (R), Optos (F); Ben Isselmann, None; Zhichao Wu, None; Emily Caruso, None; Lauren Hodgson, None; Pyrawy Sivarajah, None; Elizabeth Baglin, None; Robyn Guymer, Apellis (C), Bayer (C), Novartis (C), Roche (C); Chi Luu, None
  • Footnotes
    Support  1) BONFOR GEROK Program, Faculty of Medicine, University of Bonn, Grant No O-137.0026 to ST; 2) BM-Axis Funding to ST; 3) NHMRC APP1084081 to CL
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1831. doi:
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      Sarah Thiele, Ben Isselmann, Zhichao Wu, Emily Caruso, Lauren A.B. Hodgson, Pyrawy Sivarajah, Elizabeth Kate Baglin, Robyn H Guymer, Chi D Luu; Longitudinal changes in ellipsoid zone relative reflectivity in eyes with and without reticular pseudodrusen in intermediate age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1831.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The ellipsoid zone (EZ) reflectivity on spectral-domain optical coherence tomography (SD-OCT) imaging is assumed to derive from the photoreceptors’ mitochondria and is regarded to be an indicator for the photoreceptors’ health. Since reticular pseudodrusen (RPD) are a recognized risk factor for progression in age-related macular degeneration (AMD), the purpose of this pilot study was to determine longitudinal changes in EZ relative reflectivity in eyes with and without RPD.

Methods : Horizontal SD-OCT line scans through the fovea of eyes with and without RPD were obtained from an existing AMD natural history cohort, in which SD-OCT was performed every 6 months over 3 years. RPD eyes had definite and extensive presence of RPD on multimodal imaging. Eyes without RPD were those without RPD for the entire study duration. SD-OCT raw images were used to quantify the reflectivity (a grey value ranged 0-1) of the EZ and the external limiting membrane (ELM) at 7 retinal locations up to 8.9° from the fovea. The changes in the EZ relative reflectivity (expressed as EZ:ELM ratio) over time were determined and compared between groups with and without RPD.

Results : Ten subjects (10 eyes) with RPD (mean age of 74.3 years) and 10 subjects without RPD (68.5 years) were included in this pilot study. At baseline, the mean (± standard deviation) EZ relative reflectivity of eyes with and without RPD was 38.3 ± 30.1 and 37.0 ± 20.3, respectively. Over a review period of 3 years, there was a trend of a greater reduction in the EZ relative reflectivity in eyes with RPD (on an average of -12.4 ± 20.8) compared to eyes without RPD (-0.9 ± 15.1, p = 0.1942).

Conclusions : iAMD eyes with RPD showed a trend towards a more pronounced decrease in EZ relative reflectivity over time compared to iAMD eyes without RPD. These findings warrant further studies evaluating the EZ relative reflectivity as a potential biomarker for AMD severity and progression in a larger cohort.

This is a 2020 ARVO Annual Meeting abstract.

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