June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Retinal vascular density in age-related macular degeneration on optical coherence tomography angiography
Author Affiliations & Notes
  • Sophie Camille Lee
    Ophthalmology, UC Davis, Granite Bay, California, United States
  • Steven Tran
    Ophthalmology, UC Davis, Granite Bay, California, United States
    Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States
  • Aana Amin
    Ophthalmology, UC Davis, Granite Bay, California, United States
  • Lawrence S Morse
    Ophthalmology, UC Davis, Granite Bay, California, United States
  • Ala Moshiri
    Ophthalmology, UC Davis, Granite Bay, California, United States
  • Susanna S Park
    Ophthalmology, UC Davis, Granite Bay, California, United States
  • Glenn Yiu
    Ophthalmology, UC Davis, Granite Bay, California, United States
  • Footnotes
    Commercial Relationships   Sophie Lee, None; Steven Tran, None; Aana Amin, None; Lawrence Morse, None; Ala Moshiri, None; Susanna Park, None; Glenn Yiu, NIH K08 EY026101 (F), NIH R21 EY031108 (F)
  • Footnotes
    Support  NIH K08 EY026101, NIH R21 EY031108
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1833. doi:
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    • Get Citation

      Sophie Camille Lee, Steven Tran, Aana Amin, Lawrence S Morse, Ala Moshiri, Susanna S Park, Glenn Yiu; Retinal vascular density in age-related macular degeneration on optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1833.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : While the choroid is known to be involved in the pathogenesis of age-related macular degeneration (AMD), the role of the retinal vasculature is unknown. This retrospective cross-sectional study compared retinal vascular measurements between eyes with non-exudative and exudative AMD using optical coherence tomography angiography (OCT-A).

Methods : We evaluated OCT-A images of 310 eyes (182 patients, mean age 78.8 ± 8.8 years) with non-exudative (54.2%) and exudative AMD (45.8%) to measure retinal vessel density (VD) in the foveal, parafoveal, and full 3mm macular region, and foveal avascular zone (FAZ) area, perimeter, and circularity in the superficial capillary plexus. Multivariate regression analyses were used to compare eyes with non-exudative and exudative AMD, adjusting for age and central subfield thickness (CST), as well as the impact of anti-vascular endothelial growth factor (anti-VEGF) treatments or geographic atrophy (GA).

Results : In eyes with AMD, VD decreased with age in the foveal, parafoveal, and full macular regions (β = -0.211, P < 0.001; β = -0.305, P < 0.001; β = -0.295, P < 0.001). Eyes with exudative AMD showed significantly lower VD in foveal, parafoveal, and full regions as compared to eyes with non-exudative AMD (13.6 ± 7.2% vs. 16.7 ± 6.7%, P = 0.002; 29.8 ± 6.3% vs. 33.0 ± 5.7%, P < 0.001; 27.9 ± 6.2% vs. 31.2 ± 5.5%, P < 0.001). There was no difference in FAZ area, perimeter, or circularity between the two groups (P = 0.503 – 0.907). In eyes with exudative AMD, anti-VEGF treatments did not affect VD or FAZ measurements (P = 0.324 – 0.986). In eyes with non-exudative AMD, eyes with central GA also had lower VD in the parafoveal and full regions compared to eyes with no GA (28.7 ± 5.3% vs. 33.9 ± 5.2%, P = 0.007; 26.9 ± 4.9% vs. 32.0 ± 5.1%, P = 0.005).

Conclusions : Retinal VD is decreased in eyes with exudative AMD compared to eyes with non-exudative AMD, suggesting a retinal vascular component in the pathogenesis of AMD.

This is a 2020 ARVO Annual Meeting abstract.

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