Investigative Ophthalmology & Visual Science Cover Image for Volume 61, Issue 7
June 2020
Volume 61, Issue 7
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ARVO Annual Meeting Abstract  |   June 2020
Anatomical Relationship Between Bruch’s Membrane Opening Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer Thicknesses: Comparing Outcomes of the Automatic and Clinical Delimitation of Optic Nerve Head Boundaries.
Ligia DE FENDI Arruda; Jayter Silva Paula; C Gustavo De Moraes; Bruna Melchior Siilva; Vitor Joaquim Barreto Fontes; Marcelo Jordao Silva; Zane Zemborain
Author Affiliations & Notes
  • Ligia DE FENDI Arruda
    Department of Ophthalmology, USP - Ribeirão Preto Medical School, USP-RP, Ribeirão Preto, Sao Paulo, Brazil
  • Jayter Silva Paula
    Department of Ophthalmology, USP - Ribeirão Preto Medical School, USP-RP, Ribeirão Preto, Sao Paulo, Brazil
  • C Gustavo De Moraes
    Bernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Irving Medical Center, New York, New York, United States
  • Bruna Melchior Siilva
    Department of Ophthalmology, USP - Ribeirão Preto Medical School, USP-RP, Ribeirão Preto, Sao Paulo, Brazil
    Bernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Irving Medical Center, New York, New York, United States
  • Vitor Joaquim Barreto Fontes
    Department of Ophthalmology, USP - Ribeirão Preto Medical School, USP-RP, Ribeirão Preto, Sao Paulo, Brazil
  • Marcelo Jordao Silva
    Department of Ophthalmology, USP - Ribeirão Preto Medical School, USP-RP, Ribeirão Preto, Sao Paulo, Brazil
  • Zane Zemborain
    Psychology, Columbia University, New York, New York, United States
  • Footnotes
    Commercial Relationships   Ligia Arruda, None; Jayter Paula, Allergan Inc., Brazil (R), Phelcom Inc., Brazil (C); C Gustavo De Moraes, Belite (C), Carl Zeiss (C), Galimedix (C), Heidelberg (R), National Eye Institute (R), Novartis (C), Perfuse Therapeutics (C), Reichert (C), Research to prevent Blindness (R), Topcon (R); Bruna Siilva, None; Vitor Joaquim Fontes, None; Marcelo Silva, None; Zane Zemborain, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1967. doi:
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      Ligia DE FENDI Arruda, Jayter Silva Paula, C Gustavo De Moraes, Bruna Melchior Siilva, Vitor Joaquim Barreto Fontes, Marcelo Jordao Silva, Zane Zemborain; Anatomical Relationship Between Bruch’s Membrane Opening Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer Thicknesses: Comparing Outcomes of the Automatic and Clinical Delimitation of Optic Nerve Head Boundaries.. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1967.

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Abstract

Purpose : The anatomical relationship between Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) and circumpapillary Retinal Nerve Fiber Layer (cpRNFL) thicknesses determined by the spectral domain Optical Coherence Tomography (sdOCT) has not yet been thoroughly determined. Thus, the objective of this study is to investigate if the clinical delimitation of the optic nerve head (ONH) boundaries improves the relationship between BMO-MRW and cpRNFL.

Methods : This cross-sectional study evaluated 22 eyes of 11 healthy subjects (53.2 ± 19.6 years old; spherical equivalent: -0.3 ± 2.9 D) that underwent sdOCT examination (Spectralis, Heidelberg Engineering, Heidelberg, Germany). After acquiring the sdOCT scans for establishing both the BMO-MRW and the 3.5 mm cpRNFL, a manual edition was performed by an ophthalmologist (VJBF) based on his best clinical discretion for the delimitation the ONH rim boundaries, using en face images. Correlation coefficients between cpRNFL and BMO-MRW before ("automatic") and after ("clinical") edition were calculated for each Garway-Heath sector and compared with those computed with the Heidelberg database.

Results : Measurements taken from the Heidelberg database showed highly significant correlations for all Garway-Heath sectors, with the highest coefficient for the temporal-inferior sector (Table). Clinical delimitation of the ONH boundaries showed a slightly higher correlation between BMO-MRW and cpRNFL thicknesses for the temporal superior and inferior, nasal, and nasal superior as well as for the global values than the automatic delimitation (Table).

Conclusions : The anatomical correlation between BMO-MRW and cpRNFL thicknesses was overall improved after a clinical delimitation of the ONH, including the temporal superior and inferior sectors. Further studies, including both larger sample size and circumferential determinants of this relationship, may help improve the accuracy of glaucoma diagnosis.

This is a 2020 ARVO Annual Meeting abstract.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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